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* ''Anime/OnegaiMyMelody'': The cast is split between humans and living stuffed animals, so there are plenty of these. [[AllLoveIsUnrequited All of them are one-sided, mind.]]
** Kuromi is {{Yandere}} for Hiiragi and just wants to make him love her. It upsets her that he doesn't return her feelings though he does sometimes exploit them.
--> '''Kuromi''': Would it be so freakin' wrong for a human to fall in love with a stuffed animal?!
** Shiroyama was charmed by My Melody's "Please?" to help her win a battle and since then she's on his mind all the time. His infatuation gets him in a lot of trouble over the course of the series.
** The king of Mari Land crushes on humans too, particularly the weather girl on TV, and keeps an implied human PornStash. Both of these things piss off his wife greatly.

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* ''Anime/OnegaiMyMelody'': The cast is split between humans and living stuffed animals, so there are plenty of these. these besides even the ones below. It should be said ahead of time that all interspecies pairings on this show are [[AllLoveIsUnrequited All of them are one-sided, mind.one-sided.]]
** Kuromi (plush [[MixAndMatchCritters rabbit/devil]]) is {{Yandere}} for Hiiragi and just wants to make him love her.her. She fantasizes about marrying him and once even dreamed of having his child. It upsets her that he doesn't return her feelings though he does sometimes exploit them.
--> ---> '''Kuromi''': Would it be so freakin' wrong for a human to fall in love with a stuffed animal?!
** Shiroyama was charmed by My Melody's "Please?" to help Melody (also a rabbit) and her win a battle "Onegai/Please?" and since then she's on his mind all the time. His room gradually becomes a StalkerShrine to her. His infatuation gets him in a lot of trouble over the course of the series.
series, since Kuromi uses hopeless dreamers like him to further her goals.
** The king of Mari Land (elephant) crushes on humans too, particularly the weather girl on TV, and keeps an implied human PornStash. Both of these things piss off his wife greatly.

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* ''Anime/OnegaiMyMelody'': The cast is split between humans and living stuffed animals, so there are plenty of these. [[AllLoveIsUnrequited All of them are one-sided, mind.]]
** Kuromi is {{Yandere}} for Hiiragi and just wants to make him love her. It upsets her that he doesn't return her feelings though he does sometimes exploit them.
--> '''Kuromi''': Would it be so freakin' wrong for a human to fall in love with a stuffed animal?!
** Shiroyama was charmed by My Melody's "Please?" to help her win a battle and since then she's on his mind all the time. His infatuation gets him in a lot of trouble over the course of the series.
** The king of Mari Land crushes on humans too, particularly the weather girl on TV, and keeps an implied human PornStash. Both of these things piss off his wife greatly.

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** ''Anime/YuGiOhVRAINS'' gives us [[ArtificialIntelligence Ai]] and [[DefrostingIceQueen Yusaku]]. Although they start out using each other to achieve their own goals, they gradually become closer and fall in love over the course of the series (although this is much more obvious on [[LargeHam Ai's]] side than [[AloofAlly Yusaku's]]).


* ''Anime/YuGiOhGX'' has Juudai x Yubel. Juudai swore his love to her after she was transformed from a human into a humanoid dragon, and that didn't change even after death and rebirth. He just forgot about it for a while. He got better. And so did she. There's also Taniya x Misawa, even though Taniya is fairly human looking. She can just turn into a tiger and has very pointed ears. (It has been suggested that the tiger is, indeed, her true form, but this has not been confirmed.)
** GX is the series with most human x duel spirit ship tease, other examples are Sho x Dark Magician Girl (which is canon, even if they're not specifically together. Interest was shown on both sides.) and [[HoYay Fujiwara x Honest]].

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* ''Anime/YuGiOh'' has a history of doing this every two series.
**
''Anime/YuGiOhGX'' has Juudai x Yubel. Juudai swore his love to her after she was transformed from a human into a humanoid dragon, and that didn't change even after death and rebirth. He just forgot about it for a while. He got better. And so did she. There's also Taniya x Misawa, even though Taniya is fairly human looking. She can just turn into a tiger and has very pointed ears. (It has been suggested that the tiger is, indeed, her true form, but this has not been confirmed.)
** *** GX is the series with most human x duel spirit ship tease, other examples are Sho x Dark Magician Girl (which is canon, even if they're not specifically together. Interest was shown on both sides.) and [[HoYay Fujiwara x Honest]].Honest]].
** The ''Anime/YuGiOhZEXAL'' manga has Yuma and [[SpiritAdvisor Astral]]. While the romance is only explicitly canonical in the manga, the anime portrays the same relationship, and both of them consider each other the most important person in their lives.


** And then there's the recently revealed MagicalLand, which seems to be mostly populated with Humans, PettingZooPeople, some {{Funny Animal}}s, even the odd demon. All of this little world is implied to happily mingle and [[HalfHumanHybrid reproduce]] without much regard for species.

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** And then there's the recently revealed MagicalLand, which seems to be mostly populated with Humans, PettingZooPeople, some {{Funny Animal}}s, even the odd demon. All of this little world is implied to happily mingle and [[HalfHumanHybrid reproduce]] without much regard for species.

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* ''Anime/NeonGenesisEvangelion'' has Rei and Shinji, which doesn't seem too unusual until she is revealed to be a SoulJar for an EldritchAbomination.


* Lawrence and Holo in ''LightNovel/SpiceAndWolf'': a human and a {{trickster}} giant wolf who takes the form of a young girl ([[LittleBitBeastly + tails/ears]]) for almost all of the time. In volume 3 of the light novels/the first arc of the second season, after suffering a great psychological blow, she [[spoiler:offers herself to Lawrence, thinking a child they could have together would keep her from being so lonely]]. Lawrence gets to thinking about this as well, and asks Deanna whether there is any record of human-deity couples. Apparently, there have been many. [[spoiler:At the end of the series, the two are together and expecting a child after all.]]

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* Lawrence and Holo in ''LightNovel/SpiceAndWolf'': a human and a {{trickster}} [[TheTrickster trickster]] giant wolf who takes the form of a young girl ([[LittleBitBeastly + tails/ears]]) for almost all of the time. In volume 3 of the light novels/the first arc of the second season, after suffering a great psychological blow, she [[spoiler:offers herself to Lawrence, thinking a child they could have together would keep her from being so lonely]]. Lawrence gets to thinking about this as well, and asks Deanna whether there is any record of human-deity couples. Apparently, there have been many. [[spoiler:At the end of the series, the two are together and expecting a child after all.]]

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* ''Manga/TheSevenDeadlySins'' has Ban, a human and Elaine, fairy. They met when Ban came looking for the FountainOfYouth, which Elaine was guarding. Ban decided against drinking it after finding out doing so would destroy the Fairy Forest, but after the forest was attacked by a Red Demon and both Ban and Elaine are fatally wounded, Elaine gives him water from the fountain ([[IntimateHealing via a kiss]]) and after killing the demon and watching Elaine die, he tries very hard to resurrect her. Later on, she is brought back to life.

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* The premise of the series ''Manga/KitsuneNoYomeiri'' is basically that of a modern romcom version of the traditional kitsune/human relationship from Japanese folklore.


* In ''Anime/DarlingInTheFranxx'', we have [[spoiler:Hiro (human) and Zero Two (klaxosaur-human hybrid)]]. Their relationship's backstory and progression prove to be pivotal to the series' plot, especially from [[WhamEpisode Episode 13]] onwards.

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* In ''Anime/DarlingInTheFranxx'', we have [[spoiler:Hiro (human) and Zero Two (klaxosaur-human (klaxo-sapien/human hybrid)]]. Their This is later subverted [[spoiler:when Hiro transforms into a klaxo-sapien/human hybrid as well, making him the same species as Zero Two]]. Nonetheless, their relationship's backstory and progression prove to be becomes pivotal to the series' plot, especially from [[WhamEpisode Episode 13]] onwards.


* In ''Manga/{{Beastars}}'' interspecies relationships aren't unheard of. The amount of social stigma regarding it depends on the species involved. Animals of similar size and shape can get together without issue, but herbivore/carnivore relationships are seen as perverse.

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* In ''Manga/{{Beastars}}'' interspecies relationships aren't unheard of. The amount features the predator-prey relationship of Legosi (wolf) and Haru (rabbit). Being the setting that it is, their animal instincts and social stigma regarding it depends on the species involved. Animals of similar size and shape can get together without issue, but herbivore/carnivore relationships pressure are seen as perverse. a huge obstacle in their relationship, which Legosi constantly tries to fight.



* ''Manga/{{Beastars}}'' features the predator-prey relationship of Legosi (wolf) and Haru (rabbit). Being the setting that it is, their animal instincts and social pressure are a huge obstacle in their relationship, which Legosi constantly tries to fight.


* In ''Anime/DarlingInTheFranxx'', we have [[spoiler:Hiro (human) and Zero Two (klaxosaur-human hybrid)]]. Their relationship's backstory and progression prove to be pivotal to the series' plot, especially from Episode 13 onwards.

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* In ''Anime/DarlingInTheFranxx'', we have [[spoiler:Hiro (human) and Zero Two (klaxosaur-human hybrid)]]. Their relationship's backstory and progression prove to be pivotal to the series' plot, especially from [[WhamEpisode Episode 13 13]] onwards.


* In ''Anime/DarlingInTheFranxx'', we have [[spoiler:Hiro (human) and Zero Two (klaxosaur-human hybrid)]]. Their relationship's backstory and progression prove to be pivotal to the plot by Episode 13.

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* In ''Anime/DarlingInTheFranxx'', we have [[spoiler:Hiro (human) and Zero Two (klaxosaur-human hybrid)]]. Their relationship's backstory and progression prove to be pivotal to the plot by series' plot, especially from Episode 13.13 onwards.

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* In ''Anime/DarlingInTheFranxx'', we have [[spoiler:Hiro (human) and Zero Two (klaxosaur-human hybrid)]]. Their relationship's backstory and progression prove to be pivotal to the plot by Episode 13.


** Shiori and Jinenji, two characters that Inuyasha and Co. befriend, are products of this trope. Shiori's father was the prince of a bat youkai tribe, whereas Jinenji's father's species isn't mentioned (but due to his size, it's been speculated that he might have been a horse youkai).



** Koga, a wolf-youkai, has an unrequited crush on the human Kagome.

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** Koga, a wolf-youkai, has an unrequited crush on the human Kagome. [[spoiler: He marries a full-blooded youkai girl later, however.]]

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