Okay, so this review made quite a while back was negative. But last year, I decided to give the show a second chance and I LOVED it. I guess I just caught the weaker episodes early on. I will say that the show certainly isn't for everybody; the humor style is a mix of odd, quirky, and a little annoying. It's a show that you might not get right away, or ever like at all.
Now, for my positive words... The show is different from other animated adult shows currently on air. It doesn't derive humor from its characters acting like horrible people. The characters are flawed, but still nice and likable, people. Similar to the classic Simpsons era, many episodes are about them trying and usually failing. Like King of the Hill, the show is fairly grounded in reality, it doesn't go too far out. It's refreshing to see something different, both in the stories and the characters. They don't just rehash the typical sitcom formula.
Bob, the father, is the straight man of the group, trying to succeed in his business and raise his family. And he loves his family, he loves spending time with them, rather than many sitcom dads who see their family as something that's holding them back. Linda, rather than being the typical sitcom mom, is the wild and silly one in the relationship. Both parents are supporting of their kids, even when they do odd or unconventional things. Whereas most shows have the parents freak out (humorously) when their kid does something "weird", it's really nice to see a show where the parents are more accepting. The kids are pretty fun, with youngest Louise being an aggressive wild child who usually leads the other two around. Middle child Gene is an enthusiastic music-lover. Oldest child, Tina, is my favorite. She's a fangirl character you don't don't see in many lead roles on TV or movies. Her sexuality is developing and she obsessively writes fanfiction (and friend-fiction) but the show never mocks her for this or acts like there's something wrong with her. She has some insecurities but has many moments of confidence, and many a teenager (or former teenager) can relate to her. It's no wonder she's become such an internet darling.
If you decide to give the show a shot, I recommend watching at least a few episodes. First half of season one is a bit weak and doesn't offer the best qualities of the show.