Moved this to UnwinnableByMistake.Other Video Games, becuase, while I'm not familiar with the game, this doesn't really sound like something that "insane" or unlikely to happen in a playthrough:
* In the original Just Cause the second-to-last mission involves chasing something down and destroying it in a super-fast jet. Some people assume the jet will be useless after this mission and feel free to bail out of their jet as soon as said target is destroyed. The game will then autosave while you're in freefall or parachuting to safety, and you will find out quickly that you needed that jet for the next mission. At best, the jet will be just out of reach of your grapple and zoom away into the distance without you. If you're unlucky, it smashes into the ground in a fireball. You then have no choice but to start the game again, as during these final missions you can't go into free roam and access the mission again that way.