Nagato Yuki: The Techno Babble says basicly that she is an artificial program built into the fabric of the universe by the Data Intergrated Thought Entity, which basicly is the same thing, but without an 'avitar' body, so it's the Milky Way's invisible, untouchable Sysadmin.

What counts as "artificial"? Adam and Eve were made by God from dust and a rib, respectively. Are they artificial? In the Enuma Elish the first humans were made from the blood of a slain deity/Eldritch Abomination. Are they artificial?