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Could it be one of the Dr. Brain games?
Millie's Math House?
Not either of these sorry, although the style was more similar to Castle of Dr. Brain than Millies Math House. If it helps, the movie Meet the Robinson's strongly reminded me of this game. I think each room had a zany family member to tell you what to do
Le bump, any help at all is greatly appreciated
Could it have been one of the Rave entries in Math Blaster? Not a family, but featured several quirky houseguests in some entries.
Ha! Found it on Serious Game Classification, it's called The Fennels Figure Math made 1996.
I played this about 10 - 15 years ago. It was set in a crazy house where each room covered a different kind of math. I most clearly remember the volcano room, that taught about temperature, and I believe the bathroom covered volume. It wasn't an action kind of game, I'm pretty sure it was mainly point and click. I've been googling this for a while, but any help would be greatly appreciated.