Shotgun: Useless most of the time if you have better weapons. Ammo's not that tight. Acceptable against assassins.
Buster gun: Deals much more damage than the other level 1 or 3 weapons. Pretty good for assasins, since you'll be ready for them every time they appears. Ammo vanishes in the blink of an eye.
Detonator: This one's special. If you invest in enough strength, dropping down, detonating and jumping back up is a safe way of dealing with Berserkers or soldiers on a different floor than you who won't back away from the spot you have to enter. It's much faster than the kick and complements it well if you use this to be the "first hit" and either run to where they land or back up and wait until it recharges. Also good for killing turrets and, if you're in a hurry, doors. Mostly though it's free.
Reflector: Actually not that useful. There's very few locations in the game where you find yourself standing half your height below an enemy who isn't on a ramp and thus about to close that distance, so using this almost always carries the risk of being hit if you miss. It's free, but the risk to health is high.
Machinegun: Effective at long range and even against enemies who can duck or reflect. At least to the limited degree to which it's "effective" at all. The machinegun always works but always does pitiful damage.
Splintergun: This one deals damage fast enough to immobilize the victim and kills him pretty quick. The only people it's not super-effective against are Berserkers, who will reflect part of the barrage, and Annihilators, who don't flinch (but you can still do them if you're brave). Ammo doesn't last forever but doesn't vanish like the buster gun either, and in theory it actually does more damage per unit of ammo than the machinegun (if everything hits). Ideal target is Tasen Elites, who have a lot of health and good attacks but can't reflect like the berserkers. Be careful with the splash damage, it's easy to misjudge what's a safe distance and blow yourself up.
Pulse thingy: Does more damage than the machinegun, with worse range. It's safe to use at close range, or at least safe from your own splash damage, and can't be dodged or reflected, but your enemies will have time to attack back.
Hyper Pulse: If you have high strength, this weapon's very good; you can take on anything but Annihilators head on at close range. Not many weapons let you do head on or close range in this game (at least not on higher difficulties for the former). Other than the plasma cannon it's the only method of killing a berserker on extreme that doesn't test your patience. If you ignore strength, it's a slightly faster but less efficient version of the normal weapon.
Rockets: Deals 2 damage at any range. Try to shoot in the back, or while they're attacking at medium to close range (at least for troopers; berserkers will cancel their attack to reflect it). Its splash damage is more damaging than the shockspinter, so if you're firing into a wall at the enemy's feet (such as happens in level 7 a few times) use this. This is your default weapon for killing Komato Troopers and Beasts and possibly the stronger variety of Tasen. Damage isn't that special.
Spread rockets: Mostly superfluous, because the devastator still does more damage. The only thing this is good for is surprise attacks (if you sneak up behind a berserker you only get one shot of explosives), but as I said, the devastator does more damage. You can take out unaware Komato troopers in one shot. Eats ammo too fast.
Shocksplinter: An alternative to the rockets. The splash damage does less damage but over a wider area; it'll do some extra armor damage to the victim as well but likely not enough to do HP damage and you're not likely to capitalize on it. You have to be more careful about that splash damage than the rocket's. Mostly it's just the functional equivalent of rockets though.
Plasma Cannon: Poor man's nuke. This weapon is very useful, because it zaps everyone in front of you, no matter how many, for 3 damage (enough to kill Komato troopers in one shot, using the same ammount of ammo), and doesn't give them a chance to dodge or reflect. It reloads fast enough that you can attack again before berserkers have time to retaliate, but it'll take a good deal of ammo to kill them like this. Anytime you see multiple berserkers, a berserker with friends, or just a large number of troopers, use this. Also in theory should beat the snot out of assasins, but I'm not sure anymore if it works (I remember doing it before, but last time I tried it failed).
Devastator: The most powerful weapon in the game, damage per ammo or damage per shot. Knocks weak players off their feet, but same to your enemies. Don't be fooled: On extreme this will still be reliably dodged or reflected, so you have to attack from behind, but it does the job admirably. Can hit more than one enemy if the first shot is lethal. Big blast radius. Throws berserkers pretty far. If it doesn't kill outright it'll come close. Against bosses it's the only weapon that does enough damage to shave cycles off of whatever method you're really supposed to be using to kill them, which is useful since you spend a lot of time waiting otherwise (except on Iosa).
Nuke: This is the nuke. It kills everything in sight. It doesn't damage as much as the devastator, actually, and won't kill berserkers or elites, but it'll wound them and kill the rest. You don't need this explained.
MPFID: I didn't find this too useful. I guess it does a lot of damage and can't be dodged or reflected, but if you're getting this it's really just because you want the Velocithor.
Velocithor: It's like the plasma cannon plus the nuke, but more ammo efficient. You can and should shoot through walls for much cheaper than the nuke, and like the plasma cannon efficiency depends entirely on how many foes are in front of you. Does ridiculous damage and can't be dodged or reflected. Ammo efficiency is better than you'd expect but not too good.
????: The best weapon in the game. Every shot does so much damage that the game doesn't even bother telling you how much, and hits the entire screen in front of you. Makes the final boss much easier.
edit: Can you really do that in level 4? How? Do you just have to tap the button lightly enough?
edited 23rd Apr '09 7:54:30 AM by Brickman