Realism tends to be pretty prevalent in my work, with exceptions made (and rules still being configured) for the magic element.
Alcoholism will still take a heavy toll on the body of a half-breed or a full demon, assuming they drink enough, and it will definitely
kill their innate Healing Factor
. Wounds might not heal at a normal rate (they will be faster), but for demons and half-breeds, the explanation is that their cellular processes are sped up (including energy conversion and replacement), while their bodies have much more that they can spend on the healing process (meaning that they will have a longer lifespan, if they don't overdo things). Their metabolisms, as well. However, they still have to set broken limbs to splints, sew things closed, and keep injuries relatively free of stray particles. If they don't, it won't necessarily kill
them (depending upon the nature and severity of the injury), but it won't feel as pleasant. They can also use their own stores of demonic energy to help them, if they want to. This weakens them, though, depending on how much they have to start with.
With the rest of them, their skeletons are augemented by thicker bones, their heart and lungs are both
enlarged, and their organs have different placement (plus stronger tissue). Their soft connective tissue is much more durable (mine's weaker than that of the average person, so I know what happens when the connective tissue has a defect), and their muscles can withstand more lactic acid breakdown.
And as for the squishy parts, that would be their throats, which one of my characters uses her fangs to kindly remove. In fact, the one weakness that everything shares in this work (aside from being mortal in some sense of the word), is that the throat is a vulnerability. Along with the heart, but the throat is more easily reached, especially if you're a Lightning Bruiser
like she is, and can get to it quickly.
I've tried to keep the political and social elements as realistic as possible, at least partly to facilitate my main conflicts. Because Real Life
is more fun that way, and it gives me some pretty clear boundaries within which to work.