Not very far with me, but mostly it depends on the issue being discussed. Like, apparently there are people who think the states should be able to make their own little versions of foreign policy, especially as regards deporting illegal Mexicans. That... has not gone down well, considering how discriminatory that is. That is definitely something that we need to be uniform, because it involves dealing with external forces rather than just internal issues.
As far as determining gay marriage rights; well, we probably wouldn't have that being legal anywhere if we left it up to federal regulation. Not because people aren't for it, but because the Religious Right currently has a lot of pull at the federal level, and leaving that to the states has allowed marriage and civil unions to be legalized in some states.
It's... a mixed blessing, to say the least, and you'll get wildly different answers from different people.