Time ta' change da TVTropes page! :D
...yeah it does sound a lot like Megamind, but then, there has been a SLEW of Hero Antagonist animated films these days (and Megamind never really had to take a training course in order to turn good)! Doesn't that mean everyone loves a Bad Guy instead of the Good Guy?
It will be CGI because video games, regardless if 8-bit games were side-scrollers with very obvious similarities to hand-drawings, are routed in digital information, and this movies says that the film will also show examples of three dimensional platform games! Besides, Disney is now producing 3D movies as well as hand-drawn ones.
Design-wise here's my speculation
Wreck-It Ralph and Fix-It Felix: probably 80's or even 90's era arcade game
Sergeant Calhoun: Arcade shooter or Halo/Metroid
Vanellope von Schweetz: Mario Kart
I believe that Ralph will hook up with either Calhoun or Schweetz (with possibly Felix hooking up with the one left over)