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Possible cure for AIDS?
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Possible cure for AIDS?:

 1 deathjavu, Tue, 14th Dec '10 10:57:50 PM from The internet, obviously
This foreboding is fa...
Wow.

The actual study, if anyone has the time to peruse it.

...why isn't this a bigger news story? Even if the success ends up being a special case, or a fraud, or overhyped, news stories love to overplay stuff like this.

(Nevermind, I just saw that the date was yesterday. Expect this in the news, then?)

edited 14th Dec '10 10:58:37 PM by deathjavu

Look, you can't make me speak in a logical, coherent, intelligent bananna.
 2 cutewithoutthe, Tue, 14th Dec '10 11:02:39 PM Relationship Status: Star-crossed
Góđberit Norđling
HOLY FRIKKIN SHIT, WHY ISNT THIS A BIGGER NEWS STORY??

Cover up!? sad just bugs me

 3 Some Sort Of Troper, Tue, 14th Dec '10 11:15:57 PM Relationship Status: Complex: I'm real, she is imaginary
Cure for HIV. Although when your treatment plan starts with "Get cancer"-bit impractical.

In other news, stem cells used to cure blindness.

They also float and can be store for up to three days in the freezer so be sure to ask your local pharmacist.

edited 14th Dec '10 11:28:39 PM by SomeSortOfTroper

Don't just tell us the facts; tell us the memes, tell us the archetypes, tell us the catchy ideas and symbolic roles that get planted in pe
 4 deathjavu, Tue, 14th Dec '10 11:28:54 PM from The internet, obviously
This foreboding is fa...
[up]Ah, whoops.

Still, it's not like stem cells are that hard to get. Not physically, at least...
Look, you can't make me speak in a logical, coherent, intelligent bananna.
 5 Tibetan Fox, Tue, 14th Dec '10 11:39:05 PM from Death Continent
Feels Good, Man
As a proof of concept, it's damn impressive. The point is this will open a door for more effective, practical and cheaper techniques in the future.
Oh, this is cool.

I wish someone could give a laconic version of the study, most of it's going over my head.

 7 Some Sort Of Troper, Tue, 14th Dec '10 11:52:42 PM Relationship Status: Complex: I'm real, she is imaginary
Guy with HIV gets leukaemia. He undergoes therapy for leukaemia, the common one which involves radiation therapy followed by a bone marrow transplant. He's not taking his antiretrovirals after this but the guy he got the bone marrow transplant from was one of those people with the gene for HIV immunity. Now leukaemia is a disease of the immune system and blood cells, the bone marrow transplant works because it replaces the blood cell producers so now the guys blood cells are being made HIV proof. At first they thought that all the previously infected cells would remain around but it appears that the reservoir of infected cells is being reduced.

That's just what i get from the abstract.

Even shorter version:

Leukaemia and HIV are both disorders of immune cells. If you insert the Immunity to HIV gene while doing your leukaemia treatment, the infected cell levels diminish while your blood gets replaced by immune cells.
Don't just tell us the facts; tell us the memes, tell us the archetypes, tell us the catchy ideas and symbolic roles that get planted in pe
Wait, what? There's an immunity to HIV gene?

 9 deathjavu, Wed, 15th Dec '10 12:00:34 AM from The internet, obviously
This foreboding is fa...
[up][up] It's not really necessary to have leukimia for this treatment though, not the way I read it. Just drop your normal T-cell levels via radiation, then replace bone marrow with stem cells...

edited 15th Dec '10 12:03:19 AM by deathjavu

Look, you can't make me speak in a logical, coherent, intelligent bananna.
 10 Some Sort Of Troper, Wed, 15th Dec '10 12:03:30 AM Relationship Status: Complex: I'm real, she is imaginary
[up][up] Yep.

HIV entry into CD 4+ cells requires interaction with a cellular receptor, generally either CCR 5 or CXCR 4.

Velcro hook viruses connect to the cells' CCR 5 protein loops.

CCR 532/32 stem cells

Dude's CCR 5 loops are all bent out of shape.

[up] No but you've got to replace all your bone marrow which is not a good thing to do unless you have leukemia and not only do you have to wait for a donor match, they have to have the CCR 5 defect.

edited 15th Dec '10 12:05:46 AM by SomeSortOfTroper

Don't just tell us the facts; tell us the memes, tell us the archetypes, tell us the catchy ideas and symbolic roles that get planted in pe
... whoa.

I wonder how many people have this noncompatibility with the HIV virus.

 12 Some Sort Of Troper, Wed, 15th Dec '10 12:28:09 AM Relationship Status: Complex: I'm real, she is imaginary
Well there are various forms of immunity or resistance but for this specific Delta 32 variation:

The article I use says "An estimated 10 percent to 15 percent of those descended from Northern Europeans have the lesser protection", that's people with the gene on only one of a chromosome pair. Full immunity requires both and will be rarer (about 1%). Also, UCL did a study on this gene and found that Africans, East Asians and Indians don't have it at all (the current theory is that this gene defect evolved due to a different disease from the medieval period- bubonic plague or smallpox depending on whether you model it as "single cataclyism" or "continuing scourge").

edited 15th Dec '10 12:30:13 AM by SomeSortOfTroper

Don't just tell us the facts; tell us the memes, tell us the archetypes, tell us the catchy ideas and symbolic roles that get planted in pe
 13 deathjavu, Wed, 15th Dec '10 12:28:14 AM from The internet, obviously
This foreboding is fa...
[up][up][up] I'd think replacing your bone marrow is better than having HIV develop into AIDS...

And yeah, the donor cells have to have the mutation but I think it'd be possible to engineer that. At least in the future.

Oh, that's what they say in the article. I should have read this better before posting it...in my defense it's 3:00 here

edited 15th Dec '10 12:31:17 AM by deathjavu

Look, you can't make me speak in a logical, coherent, intelligent bananna.
 14 carbon-mantis, Wed, 15th Dec '10 6:45:15 AM from the woods Relationship Status: They can't hide forever. We've got satellites.
Why hello there!
Hmm, I posted this in IJAM a while back and it was buried. sad

It'd be awesome if they could use this en-masse, or come up with some other, easier means of giving it to someone without them having to give a marrow transplant.

The only unfortunate thing I can think of regarding CCR 5 is that it kills your immunity to certain forms of encephalitis, if I remember correctly.

-edit- Knew I saved this link somewhere. A neat little paper on the spread of the mutation.

edited 15th Dec '10 6:54:18 AM by carbon-mantis

So, naturalists observe, a flea has smaller fleas that on him prey; and these have smaller still to bite ’em; and so proceed ad infinitum.
 15 Deboss, Wed, 15th Dec '10 7:04:55 AM from Awesomeville Texas
I see the Awesomeness.
Push for human testing of genetic modification.
 16 Tibetan Fox, Wed, 15th Dec '10 11:37:17 AM from Death Continent
Feels Good, Man
Give it time, it'll get there eventually.
Africans, East Asians and Indians don't have it at all

Fuck you evolution!

Yeah, needs moar research. Moar research is always better.

 18 Deboss, Wed, 15th Dec '10 1:23:47 PM from Awesomeville Texas
I see the Awesomeness.
To the SCIENCECRAFT!
 19 rmctagg09, Wed, 15th Dec '10 1:41:10 PM from Brooklyn, NY Relationship Status: I won't say I'm in love
The Wanderer
[up][up] I'm mixed, so my chances are slightly higher.
Hugging a Vanilluxe will give you frostbite.

It's typed rmctagg09.
 20 Oscar Wildecat, Wed, 15th Dec '10 4:38:57 PM from The Interwebz Relationship Status: Who needs love when you have waffles?
Bite Me!
The Wall Street Journal also has a writeup on this.
Please spay/neuter your pets. Also, defang your copperheads.
Her with the hat
The idea that a cure exists is awesome!

...But they still need to be able to replicate the treatment, and work out a less risky way of using the knowledge, since the transplant method has a pretty high mortality rate.
The owner of this account is temporarily unavailable. Please leave your number and call again later.
Also known as Katz
Stem cells, baby.

 23 Schitzo, Thu, 19th May '11 12:42:58 PM from Akumajou Dracula Relationship Status: LA Woman, you're my woman
#sadboys
http://www.rawstory.com/rawreplay/2011/05/san-francisco-man-becomes-first-in-history-to-be-cured-of-aids/
ALL CREATURE WILL DIE AND ALL THE THINGS WILL BE BROKEN. THAT'S THE LAW OF SAMURAI.
 24 carbon-mantis, Thu, 19th May '11 1:39:50 PM from the woods Relationship Status: They can't hide forever. We've got satellites.
Why hello there!
Wow, nice to see they've developed this more. From what I recall they've been looking at the delta 32 mutation for a few years now.

The cells were from someone else, the article says? That would mean he would still need drugs to keep his body from rejecting the cells, if I'm not mistaken. Beats dying of AIDS though.
So, naturalists observe, a flea has smaller fleas that on him prey; and these have smaller still to bite ’em; and so proceed ad infinitum.
Apparently all chimpanzees have the immunity to their equivalent of AIDS. Scientists figure they survived an epidemic, given their promiscuous sexual behavior it would've spread like wildfire...

There's a theory that the African branch of AIDS (actually a different variety than US AIDS) may have come from eating chimpanzees.
If I'm asking for advice on a story idea, don't tell me it can't be done.
Total posts: 37
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