These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
The anonymous calls that are just heavy breathing.
Leigh's trailer.
"Squirrels."
Paranoia Fuel: Be careful when someone pulls up next to you.
Lampshaded when Robert briefly thinks that Bob Vaughn is the Zodiac.
Tom Hanks Syndrome: John Ennis, Philip Baker Hall, Dermot Mulroney, Charles Fleischer, and Anthony Edwards are best known as comic actors.
The Untwist: Toschi's number-one suspect was Leigh. And he was right...according to the film, anyway.
Visual Effects of Awesome: Certain scenes featuring San Fran to be digitally created and you won't even know which ones.
To save time David Fincher decided to not use bloody makeup for the murder scenes, thus all blood is CGI.
What an Idiot - Leigh, if the informant's story is true. He basically laid out his entire murder plot to him on New Years Day, as well as saying he would call himself the Zodiac.
Complete Monster: Hell Hound. His bio gives hints(a mercenary who'd do anything for money, and would lower his price if it were particularly gruesome) but his encounter with Virgo in 196, 197 and 219 (dear God) really seal the deal.
Ensemble Darkhorse: Saurus is surprisingly popular despite being part of the Zodiac comic's Rogues Gallery. He even gets a side story dedicated to him that is set after the main story of the Zodiac comic.