These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
YMMV: Zebra Girl
Archive Binge: Oh boy. The webcomic started in 2000. Though, the webcomic is now only getting updated once every 2 weeks, so you only have over 600 strips worth of content. Please also note that the author has the tendency to regroup his strips, which means that there are actually more strips in total.
Epileptic Trees: One need only read the fan forums to find a veritable epileptic forest concerning such matters as the true nature of Mr. Chalk, the final fate of Tool, the reasons behind Sandra's Face-Heel Turn, etc.
Hilarious in Hindsight: Sandra calling sarcastly Viv "mother" in this strip. Well, when you realize that Viv is in fact Eve, and is, technically, the mother of all humanity...
Tear Jerker: The "Magi-Net" arc and especially its resolution.
The Woobie: Sandra, every now and then Crystal, and Mabel.
Crystal, full-stop, when Sandra turns evil, terrorizes the whole town, and physically and mentally tortures her and her friends. Her inability to stop Sandra, who she still considered as her best friend until her "I Know You're in There Somewhere" Fight (which fails miserably), completly breaks her.
Iron Woobie: Jack, who takes his failures as a need to make the world better at his own detriment, and eventually exiles himself into living in homelessness at some point during the Earth-years that Sandra's been in the Subfusc.