These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Archive Binge: Oh boy. The webcomic started in 2000. The update schedule varied a lot, though the autor has been keeping a weekly one for a while now (with the comic updating Saturday). The comic has over 600 strips worth of content, if not more, if you take into account the tendency of the author to regroup his strips, which means that there are actually more strips in total.
Epileptic Trees: One need only read the fan forums to find a veritable epileptic forest concerning such matters as the true nature of Mr. Chalk, the final fate of Tool, the reasons behind Sandra's Face-Heel Turn, etc.
Hilarious in Hindsight: Sandra calling sarcastly Viv "mother" in this strip. Well, when you realize that Viv is in fact Eve, and is, technically, the mother of all humanity...
Ho Yay: Crystal and Sandra deeply care for eachother. In fact, it was pointed out to Sandra that she may have romantic feelings for Crystal, even if she doesn't want to accept it.
Iron Woobie: Jack, who takes his failures as a need to make the world better at his own detriment, and eventually exiles himself into living in homelessness at some point during the Earth-years that Sandra's been in the Subfusc.
Sandra leaving the Subfusc, and saying her goodbyes to both Mabel and Viv.
The Woobie: Sandra, every now and then Crystal, and Mabel.
Crystal, full-stop, when Sandra turns evil, terrorizes the whole town, and physically and mentally tortures her and her friends. Her inability to stop Sandra, who she still considered as her best friend until her "I Know You're in There Somewhere" Fight (which fails miserably), completly breaks her.