These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Big Lipped Alligator Moment: The extremely bizarre non sequitur line from Sam the Keeper ("Mr. Niles! I just found out Count Dracula was a faggot!") in his introductory scene. Seriously, what the hell was that about?
"Weird things a goin', weird things a comin', weird things a doin', around here!"
Blooper: At one point an actress already has mud on her dress from a previous take.
Designated Hero / Pinball Protagonist: Paul Niles never performs any action even remotely heroic throughout the course of the film. Even when he finally kills the villain at the end (as a werewolf), it's treated no differently from when he killed a lot of innocent people (as a werewolf). Paul doesn't affect the plot, the plot affects Paul.
Natalie: Paul... you're our only hope.
Crow: I hope someday they tell us what he's their only hope for.
Natalie seems to think that Paul can help them get funding, presumably by writing something? It's never explained, and you'd think they'd have no problem getting funding when everyone keeps saying that the skeleton is the find of the century.
Esoteric Happy Ending: The movie ends just after it's revealed that Natalie has become a werewolf as well. So now they're both vicious creatures of the night who will undoubtedly spend the rest of their lives killing innocent people and being forced to run from the consequences. She seems pretty happy about it, though. Hooray, I guess?
"Funny Aneurysm" Moment: When the guard is driving around (and going past the same gas station over and over again), Crow remarks on the high gas prices "Where is he, Port au Prince?". Said prices are around $1.95. Ten years later, people would kill to have gas prices that low again...
Genius Bonus: "Basquiat is in danger!" The extra indeed does look like the famous graffiti artist.
Crow: He's dreaming of slimy cat puppets! Mike: A bat? A bug? What is that? Servo: It's a gorilla with a dog mask on.
They Just Didn't Care: Early on in the movie, Noel gives lots of accurate information about yee naaldlooshii (except an accurate pronunciation), highlighting the differences between them and Eurasian werewolves. Yet, all of the yee naaldlooshii in the movie act identical to werewolves.
There's no attempt to match the continuity of the filming, as seen with Yuri's hairstyles.
The werewolf skull has ears.
Neither of the guards at the university lab wear matching uniforms. Vic's is blue, the other guy's is white. The actor playing the second guard said they brought their own costumes and even though his didn't match Tony Zarindast's as Vic, Zarindast just filmed the scene anyway. While uniforms in real life typically have variations, those variants also have commonalities to tie them together; these security uniforms don't.