These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
What Do You Mean, It Wasn't Made on Drugs?: Tim & Eric have stated that even though they both smoke pot, no drugs are involved in the writing or performance, but that they can certainly make viewing more enjoyable. One sketch (of them being interviewed by Michael Ian Black) parodies the idea that drugs must be involved.
The Woobie: The abuse Will Grello suffered from his father as a child is truly horrific, including being made to cook his own dog.