* {{Fanon}}: A number of the comic's characterizations and theories gained widespread support in the fandom. And in a few cases, [[IKnewIt they turned out to be]] ''[[IKnewIt true]]''.
* HilariousInHindsight:
** Take a good look at the date on [[http://gigaville.com/comic.php?id=121 this comic]]. Puts a whole new spin on "TwentyMinutesIntoTheFuture", doesn't it?
** Mantis' persistant refusal to believe in the existence of ghosts (despite great evidence to the contrary) became even funnier after the release of ''Metal Gear Solid 4'' where Mantis appears...''as a ghost''. Possessing a'' girl'', even!
** In [[http://gigaville.com/comic.php?id=445 #445]], Liquid tells Otacon to program REX to accept any projectile on its rail gun, including a nuclear warhead. When asked why, he says that it's so REX would able to shoot down asteroids. In ''Metal Gear Solid 4'', it turns out that [[spoiler: JD, the main Patriot AI, was housed in a U.S. military satellite orbiting the Earth disguised as debris, and Liquid Ocelot planned to use REX's rail gun to launch a nuclear warhead at it so he could use GW to take control of the entire Patriot AI system.]]
** According to [[WordOfGod Hideo Kojima]], Liquid ''really does'' have a horrible grasp of genetics.
** [[http://www.doctorshrugs.com/foxhound/comic.php?id=210 Check out the]] [[VideoGame/MetalGearRisingRevengeance title]] [[http://www.doctorshrugs.com/foxhound/comic.php?id=210 of this strip.]]
** And [[http://www.doctorshrugs.com/foxhound/comic.php?id=229 this strip]] and some earlier ones make mention of Big Boss writing an autbiography. Big Boss, in Liquid's body, lets slip about his fight with The End and tries to cover by claiming he read it in his memoirs which he then claims are on Amazon. Come ''[=MGS4=]'', and apparently Big Boss' memoirs (or at least the Snake Eater mission) are now declassified.
** Doucette guessed in one strip that the reason everyone says "la-li-lu-le-lo" instead of "the Patriots" is because they are all been brainwashed into being incapable of saying "the Patriots" as a phrase and a mental override always made them say that instead. Turns out that was in fact the canon reason.
** [[http://www.doctorshrugs.com/foxhound/comic.php?id=340 At one point, Big Boss remarks to The Sorrow that the latter "play [Liquid] like a damn Stradivarius."]] Cue 2014 with ''[[VideoGame/MetalGearsolidVThePhantomPain Metal Gear Solid V: Ground Zeroes]]'' and guess what line spoken by Miller is now a meme?
** [[http://www.doctorshrugs.com/foxhound/comic.php?id=53 Big Boss says that in 1975]] he wound up in a coma. The events of ''Ground Zeroes'' occur in 1975.
** In [[http://www.doctorshrugs.com/foxhound/comic.php?id=321 #321]], Mantis reveals an experiment wherein he would try to manipulate dead bodies as he mind-controlled people, against the wishes of The Sorrow. Cue [[VideoGame/MetalGearSolid4GunsOfThePatriots Screaming Mantis]], who in ''Metal Gear Solid 4'' controls living people with a Mantis doll and dead bodies with a Sorrow doll.
** In [[http://www.doctorshrugs.com/foxhound/comic.php?id=429 #429]], Liquid's demands to the U.S. Government include a permanent trademark for "Outer Haven", the implication being that Liquid has misspelled Outer Heaven and corrected himself. Come ''[[VideoGame/MetalGearSolid4GunsOfThePatriots Metal Gear Solid 4]]'', guess what Liquid Ocelot names his [[spoiler: aquatic battle fortress]]?
** Mixed with HarsherInHindsight where in [[http://www.doctorshrugs.com/foxhound/comic.php?id=200 #200]], Big Boss's spirit takes over Liquid's unconscious body which mirrors the events of ''[[VideoGame/MetalGearSolidVThePhantomPain Metal Gear Solid V The Phantom Pain]]'' [[spoiler: where The Medic from ''Ground Zeroes'' would fall into a nine-year coma and wake up to unwittingly serve as a body double of Big Boss.]]
*** Similarly, in [[http://www.doctorshrugs.com/foxhound/comic.php?id=441 #441]], Master Miller is killed by Ocelot, [[spoiler: which the true ending of ''VideoGame/MetalGearSolidVThePhantomPain'' implied after a conversation with Master Miller and Ocelot over Big Boss and his sons goes sour]].
** Out of everyone, Mantis is the one who hates Liquid the absolute most, and is by far the person on the team he respects the absolute least, and Liquid doesn't even bother to not annoy Mantis. According to ''VideoGame/MetalGearSolidVThePhantomPain'', Mantis and Liquid are both probably the closest thing the other has ever had to a true friend, with Mantis even letting Liquids consciousness override his own to use a Metal Gear.
* MagnificentBastard:
** Despite early appearances to the contrary, Ocelot is ''still'' one of these here.
--> '''Mantis:''' But it's all ''about'' the little details! I mean, you must spend every day pretending to act like you're falsely letting on that you aren't not unbetraying someone you don't not purport to allegedly work for but really ''do''! How do you keep all this shit straight without having an ''aneurysm''?
--> '''Ocelot:''' *shrugs* Practice.
** Saladin (Big Boss) is almost certainly one of these too, with his extreme fondness for [[{{ThePlan}} plans]], especially when it comes to manipulating Liquid. Not to mention his general [[BadassLongcoat badassery]].
* MemeticMutation: "I'm covered in bees!!!"
* ShoutOut / TakeThat: Unclear, but the female half-wolves in Shadow Moses mostly only say "[[{{Webcomic/Hiimdaisy}} Hi! I'm Daisy!]]"
* TearJerker:
** The fate of [[spoiler: Berthold, looking on sadly at his master's dead body]].
** The penultimate comic, which shows us the dead bodies of all the main characters (excluding Ocelot), might also count.