It also suggests that he's drawn to Miss Piggy not just because of the Fridge Brilliance mentioned below but also because other relations haven't been fulfilling and that she was captivating in personality rather than appearance while also being something that he could take away from his sister.
Ear Worm: "Happiness Hotel" fits right in...at the...AARGH!
Don't forget the opening, starring everybody—AND ME!
"Steppin' out with a star and feelin' high!"
"Yes, couldn't we riiiiiiiide? Side by siiiiiiiide!"
Fridge Brilliance: It makes sense that Nicky would be tired of conventionally attractive women, since being the brother of a fashion designer, he naturally sees a lot of them.
Memetic Mutation: "Did you leave them in your other pants?" "I don't have no other pants!"
Uncanny Valley: After a Blinding Camera Flash gag that gives the Happiness Hotel crew exaggeratedly dilated pupils, characters who typically have Eyes Always Shut or Eyeless Faces like the Swedish Chef, Janice, Zoot, Lips and Bunsen Honeydew now suddenly have visible eyes as a result of the gag. It's a bit unsettling to see these characters who typically don't have eyes suddenly have them, especially given this is the only time that's happened for most of them.
Visual Effects of Awesome: This film outdoes The Muppet Movie's famous bike-riding scene by featuring Kermit and Miss Piggy sing a duet while riding bikes, going in circles and performing tricks in the process. And then it finishes off with an entire parade of Muppets on bicycles.