Base Breaker: His retooled personality as of Avengers The Initiative. Some see it as a realistic view of someone who's jaded with years of being a screwball hero in a dark universe. Most fans of his older series hate the fact that his personality took a complete 180 and effectively turned him into the very character type he was created to mock. It gets worse in Deadpool's 2015 series where his character was reduced to "violent and gritty because he lacks a penis."
Character Rerailment: His 2016 mini effectively served as a transition from his darker post-Civil War personality back to something closer to his original screwball personality. In the end, he stops caring about being locked in toon clown form and being considered a joke among his peers and starts trying to enjoy life again.