- Anvilicious: In the last verse of "Found a Job":
Now think about this little scene. Apply it to your life. If your work isn't what you love, then something isn't right.
- Epic Riff: The bassline of "Psycho Killer". One of the very few basslines where just the first nine notes makes the crowd go nuts.
- Face of the Band: David Byrne.
- Fan Nickname: Frantz's steady drumming led to the nickname "The Human Drum Machine".
- "Funny Aneurysm" Moment: NASA played "Burning Down the House" as a wake-up call for the astronauts on Columbia's final mission.
- Gateway Series: For lots of rock fans, the band is a gateway into Funk and all kinds of dance music.
- Genius Bonus: Inevitable with a band where three of the four members went to RISD and another to Harvard (Jerry Harrison).
- Harsher in Hindsight:
- Lampshaded by Byrne when announcing his post 9/11 performances of "Life During Wartime," saying that the song is "more inappropriate now than it was then."
- Peter Gabriel performed a piano cover of "Listening Wind" and noted that the song, about a man seeing his culture overtaken by Americans and responds with bombings, and plays it sympathetically, could not be written in the age of The War on Terror.
- Hilarious in Hindsight:
- "Swamp" includes the words "Pika! Pika!"
- In "Born Under Punches (The Heat Goes On)" David Byrne refers to himself as 'a tumbler'
- Apparently, there is water at the bottom of the ocean.
- "Found A Job", about a couple making their own shows that are better than TV, predicted YouTube and made-for-internet films and videos almost 30 years in advance.
- Nightmare Fuel: "Unison" is a demo that appears on the 2005 reissue of Remain In Light and it's a catchy, but chilling and eerie song that echoes the lo-fi sound of early Devo. It doesn't help that it opens with a sharp, ear piercing synth note.
- "The Democratic Circus" starts out like a cheerful ditty about the circus, and gradually turns into a vision of apocalypse.
- Seasonal Rot: Set in around True Stories.
- Shout-Out: A possible cryptic one in the video to "Road to Nowhere". Around 1:10...the blonde lion mane...the blue-white striped pullover...the annoyed look...you need freeze-frame to confirm she's NOT Kim Wilde.
- Sophomore Slump: Averted with More Songs About Buildings and Food. Critics and fans consider it one of their best, occasionally even an Even Better Sequel, given that their debut, Talking Heads: '77, was given somewhat unsympathetic production by Tony Bongiovi.
- Tear Jerker: "Heaven", in which heaven is like a bar where your favourite song is always being played, and nothing ever changes, and everything is always like how you left it, and that's what's good about it. Byrne later said that the idea that heaven was like a bar where nothing ever happened came from the experience of being a touring rock star, when life was constantly being interrupted.
Heaven, heaven is a place
A place where nothing, nothing ever happens
- Tough Act to Follow: The reason the band never played live again after the tour for Speaking in Tongues, as captured in Stop Making Sense. As explained in the "self-interview" available on the DVD, the band would only tour if they felt they had something new to say rather than just supporting a new album.