These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
YMMV: Spoiler Warning
Black Hole Sue: In the post of the final episode of the Assassin's Creed II LP, Shamus declares Ezio to be one.
Cliché Storm: How they envision Half-Life 2 as made by anyone but Valve.
Ensemble Darkhorse: While they all have other characters they like in the Mass Effect series, they all love Mordin. Shamus even comments the first time they meet Mordin is the first time the entire Spoiler Warning crew stops snarking and listens.
Genius Bonus: When Rutskarn proposes keeping a count of all the Skyrim characters they want to kill who are protected by Plot Armor, Shamus advises not storing it in a 16 bit integernote Assuming its an unsigned integer (unsigned basically means "can't be a negative number") Shamus is expecting to encounter at least 65,536 such characters
Good Bad Bugs: They've encountered several in each game they've played, somehow managing to find multiple in Half-Life 2 of all things.
Hilarious in Hindsight: During the Shadow Broker DLC, Shamus complained of the Shadow Broker's spaceship base as too over-the-top villainous, even making comparisons to Bowser. Then it turns out that the Shadow Broker was actually a giant monstrous alien that wasn't too dissimilar to Bowser in appearance.
Mumbles: Don't worry Josh, Mordin's got this covered.
Although to be fair, Mordin did clear an entire room on his own once.
Rooting for the Empire: In Fallout 3, the group soon decided that the Enclave was really not much better than idiotic Brotherhood of Steel since both groups are fighting just to flip a switch.
The Scrappy: Certain characters/factions quickly earn their ire.
Fallout 3: Three Dog (for his moralizing and railroading the player to go fix his satellite to progress the plot) and the entire Brotherhood of Steel for Character Derailment and warring over the right to flip a switch.
Mass Effect 2: Miranda Lawson and Jacob Taylor (the former for being an incredibly stuck-up and smug bitch and the latter for being nothing more than The Generic Guy). Cerberus as a whole serves as their Berserk Button due to Shepard being railroaded into being associated with them and no in-game way to actively work against them until the end.
Fallout: New Vegas: Once again, the Brotherhood of Steel are despised, though this time it's for their immensely assholish (but canon) attitude. Similarly, the Boomers are also disliked due to their tendency towards firing upon anyone that comes at them and their tedious quest chain.
Mass Effect 3: Kai Leng is not only this, but an outright Berserk Button. In the case of James Vega, Shamus and Josh stated that while his appearance is initially off-putting, he was Rescued from the Scrappy Heap after they actually took the time to talk to him (though this doesn't stop Rustkarn from mercilessly mocking him).
Dishonored: The Outsider is generally disliked because of his incredibly bland voice actor and how despite being an eldritch god he failed to be interesting in any way.
Skyrim: Rutskarn has implied that there'll be many, mostly ones they can't kill due to Plot Armor. Maven Black-Briar will almost definitely be this.
Scrappy Level: The group hated Little Lamplight because of the extreme Plot Hole it represented. And because the kids weren't killable.
The first level of Tomb Raider (2013) was disliked by Shamus and Chris because it had set up the personality and gameplay mechanics in an awkward and disjointed way.
The final boss battle for Tomb Raider also counts.
Any level with massive amounts of shootouts as a general rule gets this.
Shipping: There's a certain subset of the fandom that sees Mumble's back-and-forth trolling with Rutskarn as this.