Love It or Hate It: Those who love it love it for Neil Patrick Harris 's vocal performance as Peter Parker/Spider-man, the slick animation, and the more mature atmosphere compared to other Spider-man series, those who hate it detest it for a lot of stupid original villains (because it was suppose to take place in continuity with the movie series they couldn't use too many of the classic rogue's gallery) and MTV's stupid stupid guidelines like not allowing any "old people" on the show preventing Ensemble Darkhorse J.Jonah Jameson for making too many appearance and Aunt May, one of the most important people in Peter's life from appearing at all.
Nightmare Fuel: The Lizard himself is full of this. The Gaines Twins, with their malicious behavior and their Mind Rape powers.
They Changed It, Now It Sucks: A lot of fans had a dislike of the show merely because most of the villains were Canon Foreigners. Of course, given that a fair amount of these villains were rather uninspired expies of popular canon villains, they may have a point.
They Wasted a Perfectly Good Plot: The show had vast potential to be the best Spider-Man series on the air, due to the fact that it was on a network with fewer censorship guidelines and featured a mature cast and could play with mature themes, not to mention its animation style. What resulted instead was standard MTV fare, largely because of executive constraints.
What The Hell, Casting Agency?: Keith Carradine as Jonah, trying desperately to emulate JK Simmons' take on the character. This bit of casting was seen as particularly strange, as Ed Asner was in the recurring cast as an anti-Spider-Man cop.