Christina wants to be Spider-Man's girlfriend. Very badly. Tara Strong, who provided her voice, is now playing Mary-Jane in the new Ultimate Spider-Man cartoon. Made even more hilarious considering Mary-Jane isn't Peter's girlfriend in said cartoon.
Nightmare Fuel: The Lizard himself is full of this. The Gaines Twins, with their malicious behavior and their Mind Rape powers.
Older Than They Think: Some took note of the Lizard talking in his appearance on the show. While the comics have portrayed him as a savage beast, this wasn't the first time he had ever spoken. His very first appearance in The '60s and his appearances on the 1981 Spider-Man cartoon and Spider-Man: The Animated Series, for example.
They Changed It, Now It Sucks: A lot of fans had a dislike of the show merely because most of the villains were Canon Foreigners. Of course, given that a fair amount of these villains were rather uninspired expies of popular canon villains, they may have a point. They also seriously despised MTV's stupid stupid guidelines like not allowing any "old people" on the show preventing Ensemble Darkhorse J.Jonah Jameson for making too many appearance and Aunt May, one of the most important people in Peter's life and a very iconic and popular member of Spider-Man's supporting cast, from appearing at all.
They Wasted a Perfectly Good Plot: The show had vast potential to be the best Spider-Man series on the air, due to the fact that it was on a network with fewer censorship guidelines and featured a mature cast and could play with mature themes, not to mention its animation style. What resulted instead was standard MTV fare, largely because of executive constraints.