These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Good Bad Bugs: The Wii version allows you, in the Noir Stages, to rescue a hostage fairly quickly in the Goblin segment by simply walking through the right bars (also meaning you don't need to open the cage in the first place.). A similar glitch is also in the first level, and requires some timing to pull of, which allows you to get in the hallway Hammerhead and his henchmen are: Get spotted, and then use a web-strike, and you'll be in the same hallway, though they'll have disappeared. Doing so, however, means that you will be unable to progress in the level and have to restart.
Marvel had previously claimed that a crossover between the mainstream and Ultimate books would mean they had officially run out of ideas. This has mainstream, Ultimate, 2099, and Noir!
Even more hilarious, as of late 2012, Mainstream and Ultimate Marvel books did cross-over, featuring both Spider-Mennote But not the Ultimate incarnation of Peter, as he had died the prior year, to boot! Oh Marvel, you so crazy. Oh, Crap. That means they're out of ideas. But then, "Iron Patriot" kinda make that obvious.
On a similar note, the same crossover reveals that Ultimate Mysterio was actually just a robotic avatar used by his mainstream counterpart, who had been travelling between the two universes.
And as if that wasn't enough, the current big Marvel event for the Ultimate universe involves mainstream Galactus threatening to destroy the Ultimate Universe after being teleported there.
One of the commercials in the Pain Factor level is a Blaxploitation themed advert for Stephen Strange, Jr, the Ultimate Dr. Strange. Becomes a Reverse Funny Aneurysm with the line "He's cheated death itself," given that by the time the game was released, Strange Jr. was dead.
Stop Helping Me!: There is no way to turn off Madame Web's hints. Reaches insane levels during the Sandman boss-fight where she'll continuously tell you to find something in the debris and to use water-barrels, often in rapid sucession. Over and over.
They Wasted a Perfectly Good Plot: A pre-order bonus is Cosmic Spider-Man suits for the four different Spidey's, the endgame features Mysterio trying to destroy all four universes... Yet somehow, the Cosmic Spidey costumes weren't worked into the storyline.