Contested Sequel: Edge of Time is seen by several fans as inferior to Beenox's last Spider-Man game, Shattered Dimensions. While some do defend it, many admit that losing Noir and Ultimate was a steep blow.
Good Bad Bugs: In the Wii version, by punching the air in the time-gate room after you beat the first phase of Anti-Venom as Amazing Spider-Man, Amazing's lines and quotes will act like Anti-Venom is still in the room, despite him being launched into another room.
Hilarious in Hindsight/Harsher in Hindsight: One of the available outfits is the suit used by Miles Morales, Peter Parker's successor in the Ultimate Universe. Flash-forward to 2012, where the 616-verse Spider-Man finally gets to meet him.
The latter trope occurs when Spidey says that he finally knows how it feels to come Back from the Dead, as a joke referring to how death isn't really anything in the Marvel universe (even specifically citing characters like Colossus and Captain America). Also within 2012, he would get his body swapped and taken off of life support by Doctor Octopus, dying.
In Superior Spider-Man #15-19, changes in the timeline have caused Miguel to be stranded in the present and Alchemax to have been founded in the present day, turning the plot of the entire game into this.
Miguel's words to Mary Jane about her and Peter having their whole future together is near heart shattering after One More Day.