* AccidentalInnuendo: Deko's "Prepare to bleed" line in his third phase, coupled with his [[ShirtlessScene shirtlessness]] and cuffing of Isa makes him sound like he's about to go full-on BDSM on the poor kid.
* AlternateCharacterInterpretation:
** [[spoiler:After seeing the full ending, serveral people have suggested that Kachi/Achi was only pretending to have lost her memory.]]
** [[spoiler:Although it could be said that it's not just an alternative interpretation, since her tone when she reveals her identity suggests that she was faking all along.]]
** [[spoiler:But that's something along the lines of {{Dubtext}} as the tone change isn't present in the original Japanese recording.]]
** [[spoiler:The backstory as explained in the European website further suggests that her amnesia was genuine. Her realizing that she has no memories is given in third-person omniscient narrator form, and happens before she meets Isa.]]
** [[spoiler:With Kachi's reveal, it's possible that the Nebulox are actually the good guys. Even though they are brutal, they were genuinely trying to protect their home from an extremely dangerous enemy who caused countless deaths and much damage.]]
** [[spoiler:They were willing to destroy the entire planet just to kill Isa and Kachi. [[NotSoDifferent Now, who was it that tried that tactic in the first game?]]]]
*** [[spoiler: It could a question of scale. After all, Kachi/Achi's group, Outer Space beings, want to ''destroy the whole Inner Space Multiverse '', not just one planet. Sacrificing one planet, to save countless others, can be seen as '''[[BlackAndGrayMorality very]]''' [[BlackAndGrayMorality moraly]] [[GrayAndGrayMorality gray]], but [[WellIntentionedExtremist relativelly understandable decision]] .]]
** [[spoiler:However, it could be that Achi/Kachi had the right idea in the first place. She could have been trying to free humanity from the Creators, because [[GoodIsNotNice they were brutal]]. Every time humanity tried to use diplomacy, they were wiped out. The Creators just wanted war.]]
* AwesomeArt : Yasushi Suzuki's official art for this game is rather breath-taking.
* BigLippedAlligatorMoment:
** Armon Ritter's [[VoluntaryShapeshifting shapeshifting]] ability lets him transform into a variety of [[EldritchAbomination giant monstrosities]]. The third and final form he takes is... [[spoiler:a school of dolphins]].
** His forms are themed after [[spoiler:[[FridgeBrilliance the evolution of life in the seas]]]], so going from [[spoiler:protozoa to seahorse to dolphin]] would be the logical progression.
** Not to mention another moment in which [[spoiler:you kill a massive boss only to see it spit a newborn baby version of itself out of its mouth. This newborn instantaneously seizes control of a crane, grabs your partner, and then attempts to [[NonStandardGameOver submerge them in lava]]. You free your partner, who seems to be emotionally just fine afterwards despite the constant danger of lava submersion, and then dispose of the little twerp. Why did it do this? [[YouKilledMyFather You killed its mom]], that's why! This moment is never brought up again afterwards.]]
* CrowningMusicOfAwesome: Stage 3.
** The Stage 7 fight against [[spoiler:Hibaru]].
** The very final part of the ending battle [[spoiler:by protecting Kachi's soul]]. Also, the music for the first part of the final boss battle.
** "Hakai", the ending theme of Isa & Kachi Mode.
** The system menu music.
* EvenBetterSequel: The first game is already great, if not [[SomeDexterityRequired requiring dexterity]] due to having to use an analog stick to control the cursor. This game is bigger (about 3 hours bigger), [[SequelDifficultySpike badder]], runs at a slick 60 frames per second throughout the game (even in cutscenes!), and the pointer-based controls give you the cursor control of a LightGunGame.
* HoYay: Between Deko and Isa:
-->'''Deko:''' "I'm really going to enjoy this. [[PreAsskickingOneLiner Prepare to bleed]]."
* {{Macekre}}: If you can understand Japanese, or have a translation of the Japanese game script, the censorship in the English subtitles is particularly jarring.
* {{Narm}}:
** The character models and English voice-acting are good sources of this.
** The scene in Stage 2 where Kachi asks Isa what "human" means. Dear ''god''...
-->''(Isa confirms for Kachi that humans have a head, two arms, two legs, etc)''\\
'''Kachi:''' "Oh, and a tail."\\
'''Isa:''' "Sure."\\
* [[{{Beat}} awkward silence]]*\\
'''Isa:''' "We don't have tails!"\\
''(Isa and Kachi laugh)''
** Stage 4, just about anything Ariana Shami says, especially "My Blood...is on FAH-YUUUUUUUUUUUUR!"
* NarmCharm: There are those who ''like'' the blood on fire line.
* NightmareFuel: [[spoiler:The battle with the Infant Keeper in Stage 6. Your partner is being lowered by a crane into slowly-rising lava and you have to raise a pair of platforms to keep up with the lava while occasionally stunning the Infant Keeper to force him to knock your partner back up. If you fail to keep up, your partner is '''[[ItsAWonderfulFailure SHOWN BEING DUMPED INTO THE LAVA]]''', resulting in a GameOver.]]
* ScrappyMechanic: Don't bother playing for score unless you're willing to draw out boss battles. Mind you, boss timers are often ''at least'' three minutes longer than needed to defeat whatever boss you're up against.
%%* SoCoolItsAwesome
* ThatOneBoss:
** Hard to pick just one, but the final boss on Hard mode is a fair contender.
** And the final phase... [[spoiler:essentially it's a harder version of the first game's final battle.]]
** The Swamp Keeper, who's the final mid-boss of Stage 4 (or the second to last mini boss if you're playing the Japanese version) which constantly fires leeches at you. The ''endboss of that stage'' is actually easier.
** [[spoiler:The rescue mission involving the Infant Keeper. Doesn't help that it's also NightmareFuel.]]
* ThatOneLevel:
** Stage 5 would be more enjoyable if touching the walls didn't stun the player for a few seconds.
** Stage 6, on account of its [[MarathonLevel sheer length]], brutal and durable enemies, and plethora of bosses, two of which have NonstandardGameOver conditions that can be triggered regardless of remaining health.