These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Anticlimax Boss: The Twelve Shinshou. They are mentioned as early as during the first trip to the Abyss, and you start to mentally prepare for an epic Boss Bonanza that requires careful conservation of resources... only to find out that they're complete pushovers who die in 1-4 turns, have trouble consistently hitting your party and yield less XP than a Random Encounter.
Kuzuryuu is very important to both sides' plans and is the only Neutral exclusive boss in the game. He ends up being relatively easy compared to Lucifer beforehand and the Shinreis afterwards.
Anvilicious: The subplot about the poor Woobie Shinto gods being imprisoned by YHVH so no one can worship them anymore is about as subtle as a sledgehammer upside the head.
Complete Monster: Shin Megami Tensei II has its twisted versions of Archangels Uriel, Raphael, and Michael, overlords of the theocratic dictatorship that has overthrown Tokyo After the End. Dividing the city into five districts, their Propaganda Machine claims they did so in accordance to the division of labor, but it is clear they favor the wealthy Central District and feel free to neglect, abuse, and slaughter outright the residents of the other four. When signs of rebellion appear in the Valhalla district, they order the Demon Lord Abaddon to devour it whole, promising to restore his angelic status if he did so; when he is finished, they cast him back into the demon world. The entirety of the Arcadia district has been lobotomized and plugged into Lotus Eater Machines, causing them to believe they live in an idyllic paradise while their physical bodies waste away; Aleph is subsequently informed the the Archangels intended to do the same to the entire planet. The workers of the Factory District have been brainwashed into slavery by the song of a Siren, who is routinely tortured by the Archangels' henchmen to keep her singing. Finally, they attempt to get Aleph and his comrade Zayin to surrender to them by holding the entire Holytown district hostage, threatening to cut off their air supply and slowly suffocate them to death.
Crosses the Line Twice: Yes, Mara appears, but he doesn't have the Hurricane of Puns surrounding him this time. No, this game has Crowley/Master Therion, who holds Sabbaths to have sex with demons and, when forbidden to by Lucifer, complains about how horny he is and decides to kill you to calm himself.
Ensemble Darkhorse: This is the game that introduced Alice as an enemy. Also, while he didn't gain his popularity until the next game, this is also the game that introduced Matador.
Game Breaker - No, not Zio. This time around it's damage and defense buffs and debuffs, which stack with themselves and last until they are dispelled, something that not every boss is capable of. But more-so is the Divine Retribution spell. It tears off a quarter of an enemy's health with an alignment opposite to the spell's caster, and it works on bosses with no reduction.
Hilarious in Hindsight - The Puck subquest, in which Daleth tries to screw you over with Infidelity Sap, and how it comedically backfires is funny by itself. However, when the reveal about Hiroko being Aleph's mom is discovered, it gets more hilarious when you realize Daleth got your MOTHER to chase him around like a lovestruck twit!
It Was His Sled: God (as in capital-G God) being the final boss on all three routes is one of the most well-known events of not only the game, but of the entire franchise.
Moral Event Horizon: YHVH ordering the total genocide of everyone not in Eden in the Law route. Satan is so horrified that his next target is YHVH Himself.
Michael, Raphael, and Uriel having Abaddon swallow Valhalla whole and later threatening to cut off Holytown's air supply. And if you do the Arcadia sidequest/Gimmel boss fight, you learn their ultimate plan: hook everyone up to a virtual reality to bring forth an artificial Thousand Year Kingdom, which also counts as an MEH crossing for the fully cooperative Gimmel.
Never Live It Down: It may not be an exaggeration to say that this game was this for God. While he's gotten more nuanced portrayals in later games, his incarnation in Megaten II is what most fans default to when they think of the Great Will.
If you strongly believe in an Abrahamic religion, have fun trying to complete the game. Because at the end of the game is a twisted version of God as the Final Boss. Unlike in SMT I, where following Law means you side with him, in this game you still fight him, and just to drive home how terrible he is, even His angels want him gone.
Frankly, YHVH is pretty creepy even if you don't believe in him, as He's smack dab in the middle of the Uncanny Valley, giving you a perpetual Death Glare, and begins the fight with a rant about how you deserve to be tortured for all eternity (said tortures described in excruciating detail) for daring to be the good guy here. Oh, and if you're playing on certain emulators, the dialogue box constantly shakes.
If you followed the Law Route, you essentially support the eradication of all life on Earth. If you chose to destroy the Arcadia System Gimmel is in control of (Chaos), everyone hooked up to it dies, it's even worse if you take Gimmel's place by inputting your data (Law) since everyone who is hooked up to the System would die anyway cursing Aleph for letting them die.
One-Scene Wonder: Crowley and YHVH, the former for his out of nowhere hilarity (I'M SO FREAKING HORNY!) and the latter for what He does as the Final Boss and Big Bad, even on the Law route.
Seinfeld Is Unfunny: In the pre-Quake days, its pseudo-3D movement was seen as interesting and different. For any gamer who cut their teeth after 1996, movement and the interface will feel like chilled molasses. Even the inclusion of an auto-mapping system and a minimap producing spell can't quite help the confusion and slowness of 3D map travel.
Signature Scene: As mentioned above, the battle with YHVH is one of the most remembered parts of the entire franchise.