Contested Sequel: The film is regarded as either better than the previous three or a step down from them.
Critical Dissonance: On one hand, while still part of a franchise where no film ever reached 40% in Rotten Tomatoes, Retribution had the best critical reception since the very first installment. On the other hand, most casual audiences thought the opposite, with some putting it up as the worst, at least until The Final Chapter came along and became even more divisive.
Harsher in Hindsight: The fact that Good Rain campaigned for gun control and is forced to use a gun anyway. Three months after the movie's release, gun control would become a hot button topic in the wake of the Sandy Hook Elementary School shooting.
Money-Making Shot: The ending of the film, which shows a fortified White House surrounded by thousands of undead creatures sent by the Red Queen to destroy all life on Earth.
Narm Charm: Wesker appearing in the White House as the symbolic president of the remnant world is as hilarious as Alice unveiling an army of psychic clones at the end of Extinction, if not more, but it highlights the kind of Magnificent Bastard he is.
Special Effects Failure: During the Moscow chase, the car becomes an obvious CGI model at points, which becomes especially noticeable once it enters the subway station.
Five minutes after Good Rain is killed, Bad Rain shows up in the same room, but no potential Cloning Blues discussion is presented. It was especially disappointing to those viewers hoping to see a Heel–Face Turn.
A cloning factory where you can manufacture large numbers of normal people and give them whatever skills, personality or knowledge you desire would have limitless potential in helping to rebuild human civilization after the devastation caused by the T-virus. However, the facility is unceremoniously destroyed without any character even considering this possibility.
Took the Bad Film Seriously: Though initially not a fan of Resident Evil, Li Bingbing studied Ada Wong's personality and mannerisms from the games and dedicated herself to her role, to the point that the producers considered her the perfect cast choice. Li even endured being Exposed to the Elements while wearing Ada's light qipao, as she refused to modify it out of respect for the source material.