Contested Sequel: Apocalypse is either a good follow-up to the first film (or at least about the same quality, that is, rather low) with increased action and improved visual effects, or an overall step down that gleefully stomps on the games's established canon.
Jill Valentine, in no small part due to Sienna Guillory's dedicated performance.
Nemesis to a degree.
Franchise Original Sin: While the first film avoided stepping on the games thanks to having its own original characters and playing with them in manner that was realistic to the franchise's universe, Apocalypse based itself on RE3's storyline and imported characters from it, ensuring the rest of the film saga would mandatorily intrude in the games's canon and butcher it with its increasingly divisive Alice arc. Most notably, this film was the one who turned Alice into an unbeatable God-Mode Sue and kicked off the tradition of including fan favorite characters from the games to be outlcassed and overshadowed by her in every possible field.
Narm: The action sequences try just a bit too hard to be spectacular, to the point that the storyboarding feels like it was done by an overcaffeinated fourth-grader. RedLetterMedia's Half in the Bag analysis of the series includes several clips of Mike, Jay and Rich reacting to these scenes with raucous laughter.