- Creator Backlash: Of a sort, since Balagueró wasn't actually involved in making this version. He initially described it as "impossible to like" because it was so similar to his original production, except for the explanation of the plague, but later said he didn't really know how to feel about it. Plaza, on the other hand, only said he was grateful to the American version for giving theirs more exposure.
- Hilarious in Hindsight: Talk about typecasting, one of the victims is the illegal immigrant girl with the ability to spread her own plague in Heroes.
- It's the Same, Now It Sucks: The film was criticized largely because it is a remake, despite the fact that the original film was never shown in America while in theaters. Problem is, it was owned by Sony, who withheld it in order for Quarantine to come out and be thought of as original. It also didn't help that it was not only a remake, but that it recreated the original film almost scene-for-scene, only significantly altering material which may have been controversial in the United States.
- Perhaps "unrelatable" might be a better word than "controversial". The ending scene's religious themes were probably removed since American culture isn't as Catholic as Spain's, to say nothing of the post-9/11 conspiracy atmosphere that replaced it. This frequent criticism tends to overlook additions such as the elevator scenes and Elise, an equivalent to whom doesn't even exist in the original. Very similar? Yes. Identical? No.
- Following a request from the actor, the last-surviving cop was also made more undisputedly sympathetic than in the original film. The original is a Jerk with a Heart of Gold.
- Slow-Paced Beginning: The first quarter of the film is a mock documentary on fire-fighters. When they finally get to the apartment building, things pick up nicely.
- Darkness-Induced Audience Apathy: Human life in Kemo is so cheap that you're going to stop caring about killing pedestrians in a few seconds.
- Demonic Spiders: Every vehicular Mook that is not a cabbie and not in a passive state is this in any level (even in the first map), but particularly the hover-trucks with their rear turrets in the fourth and last maps as they can constantly peddle you with highly damaging bullets if you manage to come close to them.
- Mines. They are everywhere. Not just stationary ones, but any vehicle in front of you is almost certain to eject one right in your face, and then there are nutcases who u-turn in front of you and then deposit a mine. They are virtually impossible to dodge if you intend to stay on the road, without crashing. Hitting a couple of them in a row will easily wreck your cab.
- Game-Breaker: The shotgun starting with the second level and available from that point on is absurdly powerful and can destroy just about any enemy in the game. Even the bosses will go down after 3-6 shots from the weapon. And it's rather ammo-efficient and laughably dirt-cheap, despite carrying only a maximum of 35 shells.
- Goddamned Bats: The Ax-Crazy pedestrians and trap-door goons out of nowhere who riddle you with machine gun fire to pester your life.
- Older Than They Think: Quarantine introduced a few key features prevalent in the game that would later make the Grand Theft Auto and Saints Row series popular: non-linear missions, drive-by shootings, gaining fares, weapon upgrades, a repair system, etc. However, thanks to the controversy surrounding its content at the time and how painfully difficult it was, the game was largely ignored and reduced to cult status. The only thing you can't do is get out of your car, a feature that is sorely lacking when compared to the later more popular franchises that were influenced by this game. Justified in this case because setting foot in the streets of KEMO can get you killed extremely quickly, as judged by the instantaneous deaths of pedestrians who get hit by any weapon thrown at them or hover-vehicle coming through.
- That One Boss: Facing the aptly-named Hoverboy in the city's park. He's the toughest boss in the game, because he flies around you, and your attacks always miss until he lands for a brief moment. Bearing in mind, the park is only the second level - things get way too hard, way too fast here. Your armor is constantly taking hits, so usually, you're not ready to face him when you get the offer to challenge him. If that weren't enough, a clone of him makes an appearance in the city projects, AKA the fourth level, as a Recurring Boss with all of the same strategies you need to defeat him.
- That One Level:
- The two boss missions that involve a guy wearing a powered-suit in the form of a bloated housefly. He constantly flies around to make your aim miss and his bullets can tear through your armor quick even with the best armor upgrade bought for that particular level. You need a gatling gun to deal with him since he moves very quickly and the shotgun isn't effective in stopping him despite the firepower. Thankfully, the two boss missions that involve him occur in two different levels: the second and fourth.
- The final mission in the final level. You must deliver a plutonium-laced bomb to the headquarters of OmniCorp so that it will blow up the building and be razed down. Problem is, the building is located in a section that has its roads shaped in a spiral pattern, and the Mooks and traps there can quickly blast your cabbie to shreds even with the best armor attached. And once the mission is completed, you'll have to find out how to get out of the spiral mazed section without dying, as likely your protection is gone thanks to those now Demonic Spiders of hover-cars. It is highly recommended that you must be completely kitted out with the best weaponry and armor before taking this mission and Save Scumming is required in order to not die.