Arc Fatigue: Like, really. Seems to be a running thing with Bleedman's comics.
Audience-Alienating Premise: More like an audience-alienating artist. While the sheer level of crossover can drive many people away, what drives even more out is Bleedman's reputation for art that borders (or in a number of cases jumps straight into) the pedophiliac. While this comic is safe for work, you can see the author's preferences if you look closely enough.
Love it or Hate it: Pretty much a base breaker. Many love the artwork and the idea of seeing their favorite cartoon characters interact with each other in a less then friendly setting. Others just see it as an over-glorified fanfic whose main pull is the art (some even disagreeing on that) with a shallow story that relies too much on shock value and melodrama.
Moe: Bell. Drawn in a style much more reminiscent of the original Powerpuff Girls than the girls themselves and refers to GIR as "GIRLY".
Narm: One of the main criticisms of the comic is that it tries a little too hard to pull the readers heart-strings.
Ron the Death Eater: She might have been a jerk, but Sam was nowhere near this evil in Medabots.
Subverted with The Reveal that it's not Sam after all, it's a robot masquerading as her.
Nope it's her, she just cyber-nized herself.
Unfortunate Implications: The story is chock full of Panty Shot moments for characters meant to be children. That'd be small potatoes since it sometimes happens in fiction, but keep in mind that the artist, Bleedman, occasionally draws things likethese, which don't paint a good picture of the artist's overall intent...