* BigLippedAlligatorMoment:
** Where Del becomes the Devil! However, it's actually a sort of hallucinatory version of BeneathTheMask, as Neal is imagining seeing Del as the horrible source of evil he (thinks he) is.
** The moment where Neal and Del briefly look like skeletons during their WildTake literally seconds before the above moment could count.
* CrowningMomentOfHeartwarming: Neal, after mentally piecing together [[spoiler: the truth about Del and his wife,]] returning to the El station to invite Del home with him for Thanksgiving dinner.
* EarWorm:
** The Silicon Teens' synth-pop version of "[[http://www.youtube.com/watch?v=j6crGAPlHyg Red River Rock]]", which plays on the soundtrack.
** And, of course, Creator/RayCharles's "[[http://www.youtube.com/watch?v=iNe5npkid-s Mess Around]]".
* FollowTheLeader:
** ''Film/DueDate'' largely copies this movie's formula.
** Same with ''Film/{{Dutch}}'', another movie about a pair of dissimilar people from different class backgrounds struggling to get home to Chicago for {{Thanksgiving|Episode}} And ''also'' written by John Hughes.
* HarsherInHindsight:
** Del talking about what his legacy is going to be "when I'm dead and buried," given John Candy's early death. Ditto the final fade-out on his face.
** In universe, Neal's response to Del's above line.
---> '''Neal:''' At the very least, the absolute minimum, you have a woman you love that you can grown old with.
* HilariousInHindsight:
** In one scene, Del talks about moving to Jamaica, getting some rum. Several years later, John Candy would star in ''Film/CoolRunnings'', [[VeryLooselyBasedOnATrueStory a fictionalized account of Jamaica's bobsled team]].
** The BLAM involving the skeletons is even more hilarious considering what happens to Marv in ''[[HomeAlone Home Alone 2]]''.
* JerkassWoobie: Sure, Neal comes off as a bit of a dick at times especially when he snaps at both the rental agent and the taxi driver, but after all he goes through, including nearly dying at least 3-4 different times, could you really blame him for reaching the breaking point?
* NauseaFuel:
** Del clearing his sinuses; Del taking off his shoes and socks on the plane; Del leaving wet towels all over the floor. PlayedForLaughs, of course.
** And that... scratching sound their first night in bed together. Whatever it is, eugh!
* OneSceneWonder:
** Edie [=McClurg=]. See ClusterFBomb.
** And Creator/KevinBacon.
** And [=Michael McKean=].
** And Creator/DylanBaker.
*** In fact almost the entire cast could count as this as only Creator/SteveMartin and Creator/JohnCandy are in more than at most three scenes.
* TheWoobie: Del, once it's revealed that [[spoiler:Marie has been dead for years and he's been homeless ever since.]]
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