"Funny Aneurysm" Moment: "A Walk in the Park" has a Running Gag where Brain gets trampled by an oncoming parade at a Disneyland knock-off. Five years after the episode aired, a cast member dressed as Pluto died when he was run over by a parade float in the Magic Kingdom.
Ho Yay: Occurs in "Pinky's Dream House", where Pinky acts like a housewife to Brain and even sings a song about how happy they'll be together before Elmyra makes his dream come true.
Misblamed: For years many viewers believed Kids' WB! executive Jamie Kellner to be at fault for the creation of this series. However, during one episode of Talkin' Toons' with Peter Hastings, it was revealed that the network, despite what the theme song says, did not meddle with the series — it was, in fact, entirely Steven Spielberg's idea!
Replacement Scrappy: Rudy Mookich for Montana Max. Elmyra's most frequently seen pets were now Mr. Pussy-Wussy and Mr. Shellbutt, taking the places of Furrball and Byron Basset (in "The Ravin!", we see that Elmyra has a pet cemetery - maybe she squeezed them to death?).