"Funny Aneurysm" Moment: "A Walk in the Park" has a Running Gag where Brain gets trampled by an oncoming parade at a Disneyland knock-off. Five years after the episode aired, a cast member dressed as Pluto died when he was run over by a parade float in the Magic Kingdom.
Ho Yay: Occurs in "Pinky's Dream House", where Pinky acts like a housewife to Brain and even sings a song about how happy they'll be together before Elmyra makes his dream come true.
Also Elmyra and Vanity White, one-sided on Elmyra's part (Vanity, like most people, can hardly stand her.)
Misblamed: For years many viewers believed Kids' WB! executive Jamie Kellner to be at fault for the creation of this series. However, during one episode of Talkin' Toons' with Peter Hastings, it was revealed that the network, despite what the theme song says, did not meddle with the series — it was, in fact, entirely Steven Spielberg's idea!
Replacement Scrappy: Rudy Mookich for Montana Max. Elmyra's most frequently seen pets were now Mr. Pussy-Wussy and Mr. Shellbutt, taking the places of Furrball and Byron Basset (in "The Ravin!", we see that Elmyra has a pet cemetery - maybe she squeezed them to death?).
The Scrappy: This show firmly cemented Elmyra as one the moment it was presented. The show already had Pinky, so there was no need for another idiot to ruin Brain's schemes.
So Okay, It's Average: A minority of viewers have said that, while the setup and characters were doomed from the start, this is still written by the same writers who had created all of the best episodes of Pinky and the Brain and, therefore, had plenty of cleaver gags and stories sandwiched between everything else that brought the show down.
Admit it, the series would have been a lot better with the rest of the Tiny Toons cast instead of the replacements mentioned above.
The basic setup of a naive little girl whose pets want to take over the world could make a pretty decent cartoon, if only it had been arrived at organically with a crew that actually wanted to do it. In fact, the show staff had earlier paired Brain up with Mindy from the Mindy and Buttons segment in an episode of Animaniacs. And the result is arguably much funnier than what this series put out.