These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Critical Dissonance: A bit of a special example, due to Pathologic being a really bizarre game. Some reviews (even positive ones) don't even call it a game. Many critics disliked Pathologic and warned against playing it, saying that it wasn't fun in the slightest and was far too bleak. Most fans of the game completely agree with this, but love the game's plot and atmosphere nonetheless.
Crowning Moment of Heartwarming: The Devotress' scenario has a lot of these, mainly since it's largely removed from the endless political scheming and Hobbes Was Right events in the other scenarios, making for a more optimistic and upbeat atmosphere. Most of it is simply about a frightened, confused girl who is nonetheless determined to help as many people as possible.
In Bachelor's scenario, you can talk down a drunk, suicidal Petr Stamatin by running all over town, finding Maria, and bringing back her promise that she would fulfill his plan for the Polyhedron.Or you can just tell him that you care about him.
Ensemble Darkhorse: It's said that Dankoski was a head of the crew of The Thanatica Laboratory, whose goal was actually cheating Death, and the Laboratory was closed by The Authorities and Professor Tehlmann. Despite having so little information, Thanatica is a frequent object of fanart and WMG.
The creepy sound of a baby crying or laughing when your reputation is decreased or increased, respectively. It doesn't help that this usually occurs after killing someone.
Similarly, the endless childrens' wailing that you hear when going near a stairway to Heaven is very unsettling. Made creepier by the implication that Petr may have actually captured childrens' souls in those constructions, as they were prototypes for the Polyhedron.
The sound effect that plays when you get infected. It sounds like a distorted, backwards nails-on-chalkboard sound coupled with creepy whisper-like sounds. It doesn't help that infection level is one of the hardest meters to manage, so this will quickly evoke feelings of dread from players due to gameplay reasons as well.
The background music for infected houses. It's extremely tense, off-key, and has a Recurring Riff that sounds like an Eldritch Abomination is trying to pry into your skull. It's guaranteed to make you extremely nervous and jumpy, especially since there are very good reasons to be nervous and jumpy in the houses. It even plays in cleansed houses, which aren't even that unsettling by themselves (they look exactly the same as normal houses).
Most of the background music qualifies, really.
Narm: In the English version, several lines of dialogue that should be serious end up becoming hilarious due to the infamously poor translation.
Paranoia Fuel: Due to the first-person perspective. There could be a disease cloud or a mugger right next to you and you won't know until it's upon you. And of course, you can't see behind you either, so you'll be whipping around to check your back quite often...