- Broken Base: Some viewers think the pacing of the film is slow, while others view it as rather fast.
- Critical Backlash: The critics were mostly mixed or negative about Pandorum and it failed at box office (though this was mostly due to many people not hearing about it), but as shown by the IMDB and Netflix ratings, many people see it as an actually good film, and others even consider it as one of the best films of the genre in years.
- Misaimed Fandom: Some critics and audiences actually believe the creatures are transformed crew members. Despite clues and Word of God saying that isn't possible.
- Narm Charm: One would think that Dennis Quaid's...erm...'emphatic' delivery of the "I SAID STAND DOWN, CORPORAL!" would incite raucous laughter, but the tone of the rest of the movie has a very subductive effect upon one's sense of humor.
- Older Than They Think: There are a lot people that think this movie is a rip off of Dead Space but little do they know that Pandorum began filming in August of 2008 before Dead Space's release.
- World of Symbolism: The film makes tons of references to Dante's Inferno.