!! [[{{VideoGame/Pandemic}} The Flash game]]:
* AscendedMeme: Pandemic 2.5 has three difficulty levels: Casual, Normal, and [[MemeticMutation Madagascar]].
* CrossesTheLineTwice
* CrowningMomentOfAwesome: Let's face it, getting that bastard known as Madagascar infected will almost certainly qualify as your own personal moment of this.
* FunnyAneurysmMoment: The untouchable Madagascar is [[http://www.bbc.co.uk/news/world-africa-24461474 at risk of a bubonic plague epidemic]] after it started cropping up in prisons.
* GameBreaker: Mimicking the flu symptoms minus everything dangerous means that your disease will spread everywhere, including to Madagascar early on, giving you plenty of points to spend on fun things like heart failure. Giving your disease moisture I and heat I also helps a lot with infecting Madagascar.
* HarsherInHindsight: Every once in a while, countries will be hit by natural disasters and other issues, some of which have happened in RealLife (such as "New Zealand gets hit by earthquake").
** The game as a whole could be considered Harsher now that there is an Ebola outbreak spreading around Africa and potentially to other countries throughout the world.
* HilariousInHindsight: Madagascar really did SHUT DOWN EVERYTHING after the "zombie incident" in Florida where a man got high on bath salts and tried to eat a homeless man's face.
* MemeticBadass: Thanks to this game, Madagascar will always be remembered as the sole area in the world that no epidemic can touch.
* MemeticMutation: "[[FanNickname President]] [[LocationThemeNaming Madagascar]], a man has coughed in Brazil!" [[http://knowyourmeme.com/memes/shut-down-everything-madagascar-pandemic-2 "SHUT. DOWN. EVERYTHING."]]"
* NightmareFuel: Imagine a disease like the ones you craft here occurring in real life. Sweet dreams! Seeing the world going to shit in the game and imagining that happening in RealLife also counts.
* ParanoiaFuel: Just reading some of the symptoms can make you start to believe you may have contracted your own (fictional) disease.
* SurprisinglyImprovedSequel: Although it's by no means bad, the original game pales in comparison to the second.
* [[ThatOneBoss That One Region]]:
** Madagascar and Peru, the only two areas in the game with only one way to infect them.
** Western Europe was the original Pandemic's Madagascar. It had no airports or water sources. If you didn't hit it quickly, it would become the last bastion of civilization. Even worse, starting in Central Europe doesn't even assure you'll get it.
* TheWoobie: Even some of the most sadistic disease-makers can feel sorry for the one ship that hopelessly sails around the world, looking for a non-existent open port.

!! [[{{TableTopGame/Pandemic}} The board game]]

* BrokenBase: Which edition has the better artwork? Some prefer the more realistic and painterly style of the first edition, while others like the higher budget TV show-esque artwork of the second. The fact that On The Brink was the only expansion to be done in the style of the first, and all future expansions are done exclusively in the second has broken the base further.
* {{HSQ}}: ''Legacy'''s first twist is that one of the diseases is incurable, and the game only gets crazier from there.
* MostWonderfulSound: Winning the [=iOS=] adaptation transforms the classic map into a globe's normal blue-green colors, with soft, victorious music playing.
* ScrappyMechanic: The roles are supposed to be randomly allocated, but this is a controversial rule given that some roles are more valued than others. This isn't so bad in the base game where there are only 7 roles and you are going get at least one or two you can build a strategy around, but as the expansions increase the number of roles to 20+, players are more likely to end up with a team that struggles to synergise well. The most common kind of HouseRules are those that allow the players to select their roles directly, or at least give them a greater degree of control over what role they are assigned. ''Cthulhu'' has the mechanic of players choosing one of two roles handed to them.

!! Both games

* SpiritualAntithesis: The board game and the flash games are this to each other. The board game sees you take on the role of the brave team who tries to save the world from 4 different diseases. The flash games see you take the role of a virus aiming to wipe out the world by plague.