- "Funny Aneurysm" Moment: Who knows how many modern day furries would infect themselves with this disease deliberately? On the other hand, this could very well be a Reverse Funny Aneurysm moment. Reika's perversion becomes potentially Narm-inducing.
- Monmow disease (and especially the part of the plot located in South Africa, where "it's impossible a white person would be contaminated"...) takes on a whole new meaning in the context of the AIDS pandemic.
- And Urabe's antics are retroactively made even more chilling by the fact that he looks like a young Gendou Ikari.
- What Do You Mean, It Wasn't Made on Drugs?: The more experimental parts of the manga, especially Urabe's hallucinations.