- Awesome Music: The soundtrack is beautiful. Even the short, simple main theme is profoundly emotional to listen to.
"I stole ten-thousand pounds, ten thousand pounds to see you.I robbed convenience stores because I thought they'd make it easier.I lived off rats and toads and I starved for you.I fought off giant bears and I killed them too"
- The full version of the main theme can be hilarious once you hear it. The TV size version lyrics go really well with the mood of the show and personality of the main character. The second verse though...not so much
- Ensemble Darkhorse: Adashino, the monocle-toting doctor that Ginko occasionally visits.
- Fan Nickname: Ginko is sometimes referred to by the fans as "Pimp-ko" for his almost superhuman ability to attract women.
- Fridge Brilliance: Ginko's remarks in episode 20 about being unsure how much longer he'll survive seem reasonable enough given his line of work, but take on a whole new level of meaning when you remember that he is most likely fated to turn into a Tokoyami one day like Nui.
- Ho Yay: Taku and Isaza, the two boys from chapter/episode 26. Taku tsuns Izasa during his first two meetings but gradually warms up to him to the point of wanting to run away from home with him. As an adult, Taku still longs to see his friend again after Isaza leaves for good without telling him, but says that it's all right when Ginko tells him Isaza is still alive and doing okay.
- Paranoia Fuel: So much. Two examples being episode 4 (Had a nightmare recently? It may become reality) and episode 17 (Don't. Ever. Close. Any. Door. Or be in any completely closed place. Not even for a second.)
- This is mostly because the Mushi and their effects seem to be based on everyday weirdness, generally stuff that in reality has perfectly reasonable explanations, but here are caused by mushi. The mushi themselves are reminiscent of the weird dust specks (often called 'floaters') that get stuck on your pupils and float about.
- Squick: Via Body Horror in season 2, episode 9. A mushi causes a breastfeeding woman to bleed and cry milk.
- More Body Horror, with Mud Grass from Zoku Shou. Plants and buds growing out of peoples' skin.
- Stoic Woobie: Ginko, aware that his days are numbered and forced to walk the earth because his presence will inevitably bring trouble to any place he stays too long. He mostly seems to have made some degree of peace with his situation and never really complains, but his reactions to other characters who have strong ties to a single place where they've settled makes it clear that he envies them, and in "Those Who Chase The Rainbow" he joins Kourou in his search as a "vacation" from his constant otherwise-aimless wandering.
- Stupid Sexy Flanders: Ginko has been known to have this effect on male fans, even Jason Miao.
- Superlative Dubbing: The English dub has been very highly regarded by both American audiences and Japanese audiences, even to the point of some of the original Japanese staff members complimenting it.
- The Woobie: Most of the side characters qualify.