** A meta example, as the movie provides one of its own. Natalie, for the first viewing of the movie [[spoiler:comes off as a manipulative, evil bitch]], but on the second viewing [[spoiler: all of her actions become immensely more justified when you realize that she knew from the beginning the protagonist had murdered her boyfriend]].
** Another is [[spoiler:whether Lenny really killed his wife or it's just another of Teddy's lies]] is left up to the audience, as there's evidence for each. There's also [[spoiler:whether or not Teddy being killed will stop his killing spree.]] And probably the most poignant one. Is Lenny a victim, being manipulated by Teddy to be a hired gun, who frees himself from Teddy's influence at the end of the movie? Or is Lenny just a serial killer with anterograde amnesia who just wants a purpose in life, even if it means deluding himself? The second has more weight than it initially appears, if one wonders what kind of life Lenny will/can have if he gets away with it.
** What about Teddy? Is he [[spoiler:just a scheming crook who manipulated a hapless amnesiac into becoming his own personal thug?]] Or is he, in fact, [[spoiler:the only real friend that Lenny has—a devoted pal who's been keeping Lenny out of jail, holding him back from becoming a full-blown serial killer, and giving him purpose and protection—all because he just wants the poor guy to be happy?]]
** ''Memento'' was one of the most critically acclaimed films of 2001 and is frequently ranked as one of the best films of [[TurnOfTheMillennium the 2000-2009 decade]], yet it didn't even receive a Best Picture Oscar nomination.
** Christopher Nolan received a Director's Guild Award nomination but was snubbed by the Oscars.
** The film did receive two Oscar nominations for Best Original Screenplay and Best Film Editing. However, considering that ''Memento'' has appeared on lists of the [[http://www.wga.org/subpage_newsevents.aspx?id=1807 greatest screenplays]] and [[https://www.editorsguild.com/magazine.cfm?ArticleID=1102 best edited films]] of all time, one could argue it should have won both nominations.
* JerkassWoobie: Natalie. [[spoiler:Yeah, she manipulates Leonard into killing Dodd and repeatedly insults him and his wife, but then you find out Leonard killed her boyfriend -- and she knew from the moment she met him, while he has no idea. Also, it's implied that Natalie does develop some genuine empathy for him later on when she gets to know Leonard and understand the truth of his condition.]] Her actions aren't ''justified'', per se, but they are very, ''very'' understandable once you know all the facts.
* MemeticMutation: "[[http://knowyourmeme.com/memes/dont-believe-his-lies Don't Believe His Lies]]" is an exploitable where Teddy's face on the corresponding Polaroid is replaced with the face of someone you believe is a ConsummateLiar, such as Creator/PeterMolyneux or [[VideoGame/DarkSouls Knight Lautrec]].
** [[spoiler: Subverted with Natalie. At first, she seems like a complete ManipulativeBitch, but as it turned out, she had good reason for doing what she did.]]
** [[spoiler: Leonard crosses this when he decides to consciously forget the truth about what happened and makes it seem as if Teddy was the one who killed his wife, just so he would still feel a sense of purpose. This in itself becomes rather blurry depending on just how you interpret [[AlternativeCharacterInterpretation Teddy's character]] and whether or not what he said was actually true.]]
** Lenny's musing on the real tragedy of his situation, which even manages to win Natalie's sympathy and forgiveness:
--->'''Lenny:''' How can I heal if I can't feel time?
** Sammy’s story, especially if you know or ''are'' someone with a condition that impairs one’s judgement so badly.
* WhatAnIdiot: Teddy, knowing what he knows about the protagonist's facts concerning the case, and knowing that [[spoiler:his own real name is John G.]], why he went within a hundred miles of this guy can at best be chalked up to [[spoiler:greedy recklessness]] and less charitably [[spoiler:just a death wish]]. At least he used an alias. Still, it's a bad idea.
%%* WhyWouldAnyoneTakeHerBack: Played with.