These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Complete Monster: Michio Yuki is possibly the single most hateful and sociopathic character Tezuka has ever created. A blackmailer, bisexual rapist, kidnapper and murderer. In one chapter, he seduces and kills (for sexual thrills) the daughter of the president of the bank he works at, fakes her kidnapping, (anonymously) extorts ransom money from her parents, then robs her father's bank and pins the robbery on the dead girl by impersonating her and finally kills her father by making him lose his grip on a precipice by throwing lit matches into his mouth. Michio does this for his own amusement. His crowning achievement would be stealing a classified military neurotoxin and slaughter as many people as he can with it in vengeance for his own mortality. He doesn't succeed, but still manages to fake his own death and get away clean. To see the man who created Astro Boy come up with someone this messed-up rattles the eyeteeth more than a tad.
Counterpart Comparison: Michio was often compared to fellow Complete Monster Johan Liebert from the manga series Monster in terms of being very manipulative, and trying to take everyone with them when they died. They were also noted to be innocent individuals until the military experimented on them.
Some Anvils Need to Be Dropped: Later on, a chapter is dedicated to how homosexuality is neither wrong nor shameful. Given how the only homosexual or bisexual characters in the story are Michio, Garai and a cameo by a (principled and outspoken) lesbian editor (and an even briefer cameo by her lover), this was sorely needed.
Then again there's a club-full of male ones, not counting the later scenes between Michio and the General whose wife he has just seduced beforehand.
The Woobie: Michio in the backstory; one of Michio's bank colleagues and his family; and Sumiko; and Shansaku Ban. Also Garai, thanks to his own and Michio's joint efforts.