Angst? What Angst?: Not because Nny forgets about his issues, at least long-term, but the man's tried to kill himself only to be stopped by TV or soda. He hops between Manic and Depressive more often than most people sleep. Probably because he goes out of his way not to sleep.
Big-Lipped Alligator Moment: That guy Nny captures and force-feeds because he hasn't cleaned out the fridge in a while. Satisfied his food is okay, he lets the guy go free without a scratch. End story.
Three pages into Johnny's Heaven escapades, we get a one-page comic of him in his torture cellar drilling a hole in some guy's head (and getting sandwiches for both himself and the newly-trepanned). The next page, he's back in Heaven.
One page, Johnny's driving a scythe through a woman's mouth and writing in his Die-ary that inside he's "pretty fucking ugly." Then he's on The Date with Devi and being nothing short of Adorkable. They Almost Kiss. One Moment KillerCurb-Stomp Battle later, and he's happily rampaging through a convenience store. ...Huh. Somewhat Subverted in that Devi does pop up again, but it's still pretty at odds with the rest of his actions.
Crack Pairing: Jimmy and Johnny (Mmy and Nny) seems to be quite popular amongst some fans, despite Jimmy being nothing but a caricature of an extremely annoying misguided fan who clearly evokes nothing but disgust in Johnny.
Johnny and Edgar used to have quite the following back in the day, for various reasons.
He mentioned in the introduction to the compilation of Wobbly Headed Bob strips in Squee's Wonderful Big Giant Book of Unspeakable Horrors that "it would seem that [the Meanwhile strips] were some of the most popular parts of the books with readers, often getting more attention than the books' title characters themselves. This angers me, and makes me want to kick strangers in the nuts, regardless of gender."
Edgar Vargas. He appears only in one chapter (a four page chapter) and dies during it, but is remembered and loved by many a fangirl. Probably because he's one of the few characters who posses any sort of decency (See the Asshole Victim entry above), and unlike Squee, he's legal.
Jimmy/Mmy. Like Edgar, he was a one-shot character, but also has plenty of fanart. See Crack Pairing above.
There's just something about a character who doesn't want to be a monster, but knows he's far too broken to ever be fixed. After committing suicide (he got better), he calls Devi and tells her that, since he will never be safe to be around, he will show his love for her by never going near her again to protect her from himself and allow her to leave her house unafraid (he fails). And when he saves Squee from a rapist, he tries to prevent Squee from turning the man into a nightmare monster... by ripping out the guy's guts to show he is just as human and as mortal as anyone. Of course, he fails to reassure the kid, but that he was trying to prevent Squee's mental scaring... Woobie.