Accidental Innuendo: Nick's line about Jimmy's extreme nausea: "I remember my first time. Shake it off, Neutron! Hah hah hah!"
Award Snub: Inverted. It was amongst the first nominees for the newly-created "Best Animated Feature" Oscar, against Shrek (which won) and Monsters, Inc.. Hardcore animation fans were offended that something so ugly and juvenile would be given such an honor.
Inferred Holocaust: No infants were present at the film's climax, which means they were left all alone in the town.... Some might have had older siblings, but can we expect all the kids to account for all the helpless babies?
Iron Woobie: Jimmy. He's constantly being picked on for his small size by other people, but that never stopped him from continuing on with his life and enjoying his small group of friends.