These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Tear Jerker: Many, but the angina attack scene is particularly heartwrenching, especially when Jack is told that he can't go back to school and he BEGS his father not to take him away from there as he finally has friends.
Of the Tears of Joy variant, there is the "Who I Want To Be When I Grow Up" report. God that was beautiful.
Drip, and to a lesser degree most of the other Sins, breathe this stuff.
The ending to "Dinner at Arloest's" is likewise particularly bad, especially when it's revealed that Arloest's sacrifice seems to have stuck at least one pair of people into Who Wants to Live Forever?.
"Been Reading Job" and "All Work And No Play" get bonus points for the casual life right before horror hits, and while the viewpoint character of "Hell Is That Noise" deserves what he gets, it's still very, very dark.
Arc XXIV—given the number because the title is Fnar Reborn.
Two For Skoodge is a big one.
The Side Arc "Lullaby" is an especially strong case.
Preemptively adding "Megan's Run", because you just know it's going to end with empty
Another Side Arc, Pikri Alitheia.
This strip, where Lita is visited in hell by her deceased mother, whose death she accidentally brought about and whose memory has haunted her through life and beyond. Lita is one of the most determined, headstrong characters in the comic, but she immediately breaks down like a little girl in her mama's arms.
Trixi & Tet.
The Woobie: Point at any character, there is a 70% probability that he or she is.
Except Drip, the Gluttonies and Kane, of course. However, Drip as a child may be one, based on what his grandmother put him through. had that not happened, Drip MIGHT have turned out differently.
Might is putting it mildly. The "How to Make a Monster" arc shows us that Drip as a child was not only repeatedly molested by his grandmother, but also constantly reminded that he killed his parents as an infant. The rationale used is questionable, at the very least. And yet? She's ''right.'' Not in the way she thinks, perhaps, but her Exact Words are correct.