Ending Fatigue: Watching this movie beginning-to-end is a serious commitment. It originally ran over three hours with intermission. Even in the two-and-a-half-hour cut usually screened now, this is a long movie and the climax goes on for a while.
Narm Charm: Pike's face when his attempt at hitch-hiking fails.
One-Scene Wonder: Almost all the celebrity cameos, but special mention to The Three Stooges who appear as firemen. They're onscreen only for a few seconds without any lines, and it's among the movie's funniest moments.
A non-celebrity stand-out is Barrie Chase, who plays Sylvester's unnamed girlfriend; she maintains a perfect stone face while go-go dancing in a bikini.
Tear Jerker: Emmeline's talk with the captain. She never wanted to be a part of this huge mess in the first place, is ignored by her husband and mother whenever she tries to speak up (If not being told out right to shut up), she ends up being the first to realize where the money is, offers to share half with the captain with the hopes that with her share she can run away from her family to somewhere nice, only to see the others have found it.
A more subtle one occurs with the Captain's phone conversation with his wife; he tells her he's had a big break in the robbery case that he's been working on for literally years, and she has absolutely no idea what he's talking about.
Values Dissonance: The argument over splitting the money specifically excludes the women as potential recipients of shares until they complain about it, though that could simply be because the dividing of the shares began with a discussion of who went down to the wreck, and those people would in turn divide with the others in their parties, or because they considered each couple to be one unit- which is why Lenny Pike and Mrs. Marcus protest and the whole arguement over how to divide the money begins.
"Weird Al" Effect There's an entire generation who barely know this movie exists at all but are intimately familiar with the Simpson's parody.
Just about every one of them are idiots to one degree or another. None of them stop to realize that the money they're going after is stolen and that they couldn't legally claim it. Plus, they were all in such a rush that by the end all their antics had gotten themselves into serious legal trouble and the majority of them in the hospital.
Mrs. Marcus stands out. Her verbal and emotional abuse and shutting down every single reasonable suggestion (apart from her sensible suggestion to give an equal share to everybody) makes the situation worse. Particularly during the final car chase, one of the Taxi drivers realizes that Culpeper's heading for the border and all they have to do is pull over and call the police. Mrs. Marcus quickly shuts him down. Had they simply done that, they probably would've avoided the final climatic mess.
The police for not pulling them over and placing them under arrest at any point for any number of crimes or holding them as material witnesses. Chances are, someone would've talked (heck, you can't get Mrs. Marcus to stop talking anyway - just let her sit for a few minutes and she'd end up giving everything away due to sheer inability to shut up).
The Woobie: Pike, Monica, and Emmeline for all the undeserved crap they go through. Culpeper too, though he's possibly a Jerkass Woobie.