These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
YMMV: I Feel Sick
Anvilicious: Corporations = death of creative ideas. Even without Jhonen saying it, you can tell this is him burning any leftover anger at Nickelodeon.
Devi: OH GOD! EDDIE? Talk, Eddie! Let me know you're not dead! C'mon Eddie! C'MON!! Eddie: Hmph...Gugh... Devi: Oh thank god! Come on! Keep talking Eddie!! Stay with me! STAY WITH ME!! Eddie: Can I touch your butt?
Crowning Moment of Heartwarming: Devi and Tenna's friendship moment at the end. Given how much shit the latter's been putting up with since the former started having issues (Hell, in this comic alone), it's really amazing that Tenna's stuck by Devi like she has. Especially since the creator is Vasquez.
Reality Subtext: Devi, much like Vasquez was at the time, transitions from creating art for herself to doing it for a corporation, and finds herself irritated at the constant demand for revisions that make no sense with her creative vision and are introduced entirely to appeal to certain demographics.