Strawman Has a Point: When the pets suspect something's wrong when the owners haven't picked them up at the ranch, Chance insists to Shadow that they abandoned them, as humans do when they don't want their pets anymore. While Chance was ultimately wrong about their owners, the reality is that pet abandonment is a serious issue that affects countless animals, and is frequently caused by careless owners who don't have the responsibility to raise pets. In the sequel, Shadow and Sassy become aware of this after learning about Riley's past.
What an Idiot: "There goes the bunny. There goes the pup. There goes breakfast."
Homeward Bound II: Lost in San Francisco
Hilarious in Hindsight: The film was likely in production before Spin City began filming, so it's funny that Carla Gugino is the voice of Delilah, the love interest for Chance, voiced by Michael J. Fox.
Sequelitis: Averted, this movie is one of the best live-action family film sequels ever.
Special Effects Failure: Fairly minor, but when Sassy comes running out from the burning house, the "kitten" she carries is obviously fake.
The Woobie: Riley. Yes, he's bitter toward all humans and cynical about the pets' family, but he has the Dark and Troubled Past to explain it — being "left...on the coldest, rainest night of the year."