* CompleteMonster:
** [[BigBad Major Thomas "Tom" Magruder]] is a [[CorruptCorporateExecutive railroad tycoon]] who has taken large parts of the Western United States from the First Nations and Government, [[GoldFever feverishly seeking a legendary lost city of gold]] called Quivira, murdering and torturing anyone who gets in his way. Years prior to the game, as a [[UsefulNotes/TheAmericanCivilWar Confederate]] Major, Magruder came to a small homestead out in the plains belonging to a benevolent doctor who helped the Apaches. When the chief tells Magruder his lust for his treasure will destroy him, Magruder shoots and [[OffWithHisHead decapitates the doctor]], [[BadBoss shooting one of his men]] for protesting his actions. In the present, Magruder hires soldiers and henchmen to wipe out anyone who gets in his way. When his henchman Reverend Reed fails to find a cross in the steamboat massacre at the beginning of the game, Magruder [[EarAche cuts his ear off]] as punishment. In addition to taking their lands, Magruder also takes to taking the Apaches as slaves and using them as target practice for his soldiers. When [[PlayerCharacter Colton "Cole" White]] confronts him for his crimes, Magruder dismisses the innocents he massacred as nothing. Ruthless and remorseless, Magruder is a man singularly seeking to satisfy his {{greed}}, no matter who he has to destroy.
** Magruder's [[TheDragon right hand man]], [[SinisterMinister "Reverend" Josiah Reed]], is a monster in his own right. Reed initiates a massacre at the game's beginning on a steamboat that takes the life of the hero Colton White's adoptive father Ned. When a prostitute named Sady refuses to give Reed answers, he throws a hatchet into her head and has the entire crew massacred. Reed is revealed to be an unhinged lunatic, every bit as bad as his violent boss. When he captures a [[HookerWithAHeartOfGold prostitute named Jenny]], Reed pointlessly slits her throat to let her die in front of Colton.
* PlayerPunch: [[spoiler: Jenny's death]].
* PortingDisaster: The PC version has more than a few graphical glitches compared to the console versions.
* TheyWastedAPerfectlyGoodCharacter: Sergeant Hollister and the Renegades. The idea of an entire fort of U.S. Army soldiers having gone not only rogue, but totally insane á la ''Film/ApocalypseNow'', seems like an interesting concept to explore, except it's never explained ''[[NoodleIncident why]]'' they're like that, or why they would work for Reverend Reed, who is in turn working for a former Confederate officer (Thomas Magruder). Indeed, if it weren't for their association with Reed, they would just seem like a mere WackyWaysideTribe.\\\
And we don't know much about Hollister himself, apart from the fact that he led the attack on the steamboat at the beginning of the game ([[OffscreenVillainy even though we don't actually see him do this]]) and he's not even introduced until much later in the game, only to be killed off two missions later. If anything, it's as though he was only introduced so that the game could have a boss battle in which Cole re-obtains Ned's rifle.