Tear Jerker: He and his brother Alex describing their parents' respective deaths in Genndy's Scrapbook.
Their father died of a sudden heart attack when Genndy was only fifteen, eventually forcing the Tartakovskys into government housing with Genndy having to work three jobs to support the family while still going to school. He describes himself as feeling numb the night it happened, just aimlessly watching Miami Vice with Alex as he tried to comprehend the tragedy.
During his first animation job in Spain, he got wind that his mother was in the late stages of cancer, which she had never told him about, and barely had time to get back to the US to be with her before she passed. Neither of his parents lived to see his career blossom.
Uncanny Valley: Plenty of his character designs, particularly background characters.