Adam DeCobray/Cobra Commander is the CEO of Cobra Industries, a business organization he uses to cover up Cobra, a ruthless terrorist group. Using Cobra to manufacture everything from weapons to plagues, Commander frames a group of soldiers who try to reveal Cobra Industries's true colors, sending them on the run for the rest of the series. When the soldiers, called "Joes," continuously meddle in his plans, Commander has the parents of the leader, Duke, kidnapped, offers a deal for their lives, then plans on killing them along with the Joes after the deal is through. Commander takes no slight against him lightly, shown when he tries to bomb a college to kill one blogger who slanders Cobra Industries, feeds a possible whistleblower to his pet, Serpentor, and seals a metal mask onto James McCullen (Destro) for leaking information about Cobra. Along with regularly attempting to starve, annihilate, and blackmail entire cities, Commander has a lethal virus developed that he plans on spreading across the world, then selling the cure only to those who can afford it. After his plan to mind-control the entire planet fails, Commander plans to use the M.A.S.S. device to transport his armies across the globe and Take Over the World. When The Joes interfere once again, he flies into a rage, brutally beats them down, then tries to drag Duke down with him when he falls over an edge. Cold-blooded and power-hungry beyond salvation, Cobra Commander once again proves himself to be far worse than his original counterpart ever hoped to be.
Dr. Mindbender is the young, sociopathic, top scientist of Cobra. Commisioned by Cobra Commander to build an army of Bio-Vipers, Mindbender happily tries to feed the Joes to them, and when one of his Vipers escapes and begins causing chaos, Mindbender goes to extra lengths to put civilians in danger. When the people of a town Cobra is plunging into a drought by building a dam begin fighting back against Cobra, Mindbender, along with The Baroness, pay Firefly to destroy the town and its inhabitants. Tracking down twin psychics, whom he located by torturing a fake medium, Mindbender captures and subjects the twins to horrific experiments. Later, The Joes accidentally release the powerful Electro-Viper onboard a ship, and Mindbender remotely targets it towards Destro's castle, completely aware of the destruction the creature would cause once it reaches land. After another of his Vipers escapes, Mindbender tortures a young boy for the Viper's whereabouts, and later tries to level Brooklyn, New York to act as a distraction while he flees The Joes. Helping build the M.A.S.S. device for Cobra, Mindbender nonchalantly tests it on Cobra's own soldiers, many of whom don't survive, and later tries to send Snake-Eyes through the machine in order to force his best friend to reveal the machine's secrets to Mindbender, then tries to kill them both once the device starts working. Doing everything for sick thrills or For Science!, Mindbender may not have been as powerful or influential as his cohorts, but he far surpassed them in sheer monstrosity.
Rescued from the Scrappy Heap: Sorta. In past incarnations, Bludd has been, mainly, a mercenary with a British accent and a bloodthirsty streak. In this version, he still is, but he sucks up punishment from the entire team and keeps going.