Animation Age Ghetto: Despite being made for an adult audience, the show was advertised as "From the producers of (the more kid-friendly) Shrek." It actually got the creators in a bit of trouble from Moral Guardians.
It also effectively killed off the possibly of computer animation being used for entertainment geared strictly at adults, as most prime-time animated shows are 2D animation.
Fridge Brilliance: The 7-11 clerk in "Catnip And Trust" who ditches work to make up with his girlfriend later reveals that, after the ordeal, they went right out and got married. This may seem like a one-off gag until you remember that Las Vegas is famous for it's drive-through chapels.
Genius Bonus: In the episode "Catnip And Trust," Sierra tells the school recruiter how she wrote an essay on "the role of lions in early Christianity." Anyone who knows what ancient Romans did to Christians knows that the lions' role was not a flattering one.
Harsher in Hindsight: The pilot episode has a scene where Sierra snarks at a knockoff of The Lion King, the movie that had previously convinced show runner and former Disney CEO Jeff Katzenberg to angrily leave the company to start DreamWorks (Katzenberg still considers The Lion King as his masterpiece). This is also ironic after DreamWorks had been accused by Disney, Pixar, and other sources for creating Disney/Pixar knockoffs themselves, making this a Take That, Us.
Hype Backlash: A rare example of this happening before the show even aired, as DreamWorks plugged the show out the wazoo during the 2004 Olympics to the point where everyone was sick of it when it finally premiered.
Magnificent Bitch: Sierra in "One Man's Meat..." when she fakes crying to con Sarmoti out of some money he won from her boyfriend in poker.
Moral Event Horizon: Tom the white trash antelope crosses this when he encourages his son to beat up on Hunter.
Overshadowed by Controversy: The show had the misfortune to debut almost immediately after the real life Roy Horn of Siegfried and Roy was allegedly attacked onstage by one of his tigersnote It was later revealed that Horn actually had a stroke, and the tiger was attempting to carry him offstage. Despite their insistence that the show continue, many felt it much too awkward at the time. A joke Lampshading this appears in "Possession" where one white lion is shunned because of something unspeakable.
Tear Jerker: Sierra is clearly hurt by her parents not believing that the catnip in her room isn't her's (it's later revealed to be Sarmoti's) and even starts trembling as she fights back tears.
"I didn't want to drugs before, but now maybe I will!"
Snack when he (rightfully) assumes that Candy dumped him. It gets Played for Laughs later.
Sierra gets another one when she breaks down crying and throws a mini-tantrum after she failed to win her boyfriend's money back from Sarmoti in a poker game. Subverted in that she was faking it to milk her grandfather's sympathy.
True Art Is Incomprehensible: In-Universe. Kate's feminist group encourages her to paint her feelings in a free-form painting. One of her group members (and, a little later, Hunter) recognize it as "anger, with a touch of hope" and the two laugh before sobbing in each other's arms, all while Larry stares at the thing, completely baffled.