These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
In the first game, applied literally with the Giant Spiders.
In both games, thri-kreen (mantis warriors). They're incredibly fast, tough, and have a paralysing bite that makes it pretty sure one of your meat shields will be incapacitated before having even a chance to strike. So much that fighting them one-by-one is actually a less favorable option than facing a swarm of them — then at least you can spam offensive spells more efficiently.
The Stoneskin spell in EotB1. For details, look here. Not surprisingly, it completely disappeared in EotB2, even for a party coming from the previous game, an exception to the Old Save Bonus.
In Legend of Darkmoon, though they are both high-level spells, the combo "Wall of Force + Cone of Cold" can be quite effective. To clarify: a Wall of Force stops all the monsters and every attack spells — except Code of Cold which can be used through it, and cover a wide area to boot. May be a Good Bad Bug since that shouldn't be possible by AD&D rules.
Porting Disaster: Apparently, a Game Boy Advance cartridge can't hold as much information as a DOS game. Who knew? Anyways, the GBA remake of the first game left out all but the four basic character classes and much of the gameplay. Instead of the first-person combat of the original, it uses an isometric system like the gold box games.