These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Most Annoying Sound: The survivors you find leave little to be desired out of their lines, which only consists of "HELP ME!", among other audio clips. It can get pretty grating and make you wish you could shoot them with no penalty.
Missed Moment of Awesome: The Big Bunyan ride has a Paul Bunyan animatronic and the best music in the game, but nothing happens except for rotating slowly as you shoot some of the mosquitoes that are all over the level.
Nightmare Fuel: This game breathes and lives this trope to the nth degree. That said, many people seem to have a fond memory of Junior, the boss of the Freak Show level.
That One Boss: Evil Marie, with a hard-to-hit weak point (it's the slash mark around her neck) which the game hardly gives you any time at all to draw a bead on as she slashes mercilessly at you.
What an Idiot: Why the hell does Jacob climb into a cannon in the middle of a circus tent filled with things trying to kill him?
Jacob clearly has a few screws loose up there, as the first thing he does when he gets out of that hell is feeding Umlaut a new token and do it all over again.