These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Darkness-Induced Audience Apathy: A few reviews have noted that the show tries too hard to offend, and as a result quickly desensitizes you to the brand of humor unless you were already a fan of it. As a result, the episodes get boring.
Dude, Not Funny!: Besides the two tropes above, some of Malloy's comments are simply mean-spirited instead of being mean-spirited and funny.
Jerk Sue: Malloy dances around the borderline of this and Karma Houdini. He is pretty much going to get away with nearly every rude comment and cruel act done at the expense of others repeatedly without getting any karmic punishment each episode (though see Too Dumb to Live and What an Idiot below). Given it is Daniel Tosh voicing him, it might have been intentional.
Nausea Fuel: Steve eating a Cheeto covered in mud, coyote snot, and bird shit.
"The Animals Strike Back" is easily one of the more disturbing episodes, where we get to see a winking moose anus of all things.
The entire show, really.
Serial Numbers Filed Off: Has been compared unfavorably to Family Guy in its later seasons in terms of humor. Its art style is also very similar to Family Guy's
Too Dumb to Live/What an Idiot: In the first episode, Malloy still went inside the redneck rapist's trailer to get his junk food fix, despite that the redneck had proof that he was a sexual predator (duct tape, chloroform, and a court order stating that he stay 50 yards away from children and small animals) and Malloy called him out on it. He didn't even leave the trailer when the guy got suited up in bondage gear and stated that Malloy was going to be stuffed.
The Woobie: Connie showed some shades of this, but becomes this once her past is revealed. Not only her parents were extremely prejudice against homosexuals and had her getting electroshock therapy by the church. When it didn't work, they simply disowned the poor girl and got a dog as a replacement, then removed her from all their photos.
Of course, other episodes show her to be as much the bitch as everyone else in the show.